Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Erlotinib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR known ✓ | P00533 | 16/20 | 0.98 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.98 |
| ▸ | GAK | O14976 | 3/20 | 0.98 |
| ▸ | ILK | Q13418 | 3/20 | 0.98 |
| ▸ | KDR | P35968 | 2/20 | 0.98 |
| ▸ | PLK4 | O00444 | 1/20 | 0.98 |
| ▸ | CIT | O14578 | 1/20 | 0.98 |
| ▸ | AURKA | O14965 | 1/20 | 0.98 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.98 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.98 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.98 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.98 |
| ▸ | BUB1 | O43683 | 1/20 | 0.98 |
| ▸ | KDM1A | O60341 | 1/20 | 0.98 |
| ▸ | JAK2 | O60674 | 1/20 | 0.98 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.98 |
| ▸ | STK17B | O94768 | 1/20 | 0.98 |
| ▸ | STK10 | O94804 | 1/20 | 0.98 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Erlotinib SCHEMBL3826918 | 0.99 | EGFR (0.98) | EGFRERBB2GAKILKKDR | |
| Erlotinib SCHEMBL1759094 | 0.99 | EGFR (0.98) | EGFRERBB2GAKILKKDR | |
| Erlotinib SCHEMBL8413 | 0.99 | EGFR (1.00) | EGFRERBB2GAKILKKDR | |
| Erlotinib SCHEMBL30362833 | 0.99 | EGFR (1.00) | EGFRERBB2GAKILKKDR | |
| Erlotinib SCHEMBL3667407 | 0.99 | EGFR (1.00) | EGFRERBB2GAKILKKDR | |
| Erlotinib SCHEMBL29351329 | 0.99 | EGFR (1.00) | EGFRERBB2GAKILKKDR | |
| Erlotinib SCHEMBL16767632 | 0.98 | EGFR (1.00) | EGFRERBB2GAKILKKDR | |
| Erlotinib SCHEMBL18563 | 0.98 | EGFR (1.00) | EGFRERBB2GAKILKKDR | |
| Erlotinib SCHEMBL21176918 | 0.98 | EGFR (1.00) | EGFRERBB2GAKILKKDR | |
| Erlotinib SCHEMBL1959332 | 0.98 | EGFR (0.98) | EGFRERBB2GAKILKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176241-B1 | A NOVEL HYDRATED FORM OF ERLOTINIB FREE BASE AND A PROCESS FOR PREPARATION OF ERLOTINIB HYDROCHLORIDE POLYMORPH FORM A SUBSTANTIALLY FREE OF POLYMORPH FORM B | HETERO DRUGS LTD (IN) | 2015-12-23 | — | — | EP | claimed |
| US-8669265-B2 | Hydrated form of erlotinib free base and a process for preparation of erlotinib hydrochloride polymorph form a substantially free of polymorph form B | HETERO DRUGS LIMITED (IN) | 2014-03-11 | — | — | US | claimed |
| US-20130252978-A1 | Novel Hydrated Form of Erlotinib Free Base and a Process For Preparation Of Erlotinib Hydrochloride Polymorph Form A Substantially Free of Polymorph Form B | HETERO RESEARCH FOUNDATION (IN) | 2013-09-26 | — | — | US | claimed |
| US-8471012-B2 | Hydrated form of erlotinib free base and a process for preparation of erlotinib hydrochloride polymorph form a substantially free of polymorph form B | HETERO DRUGS LIMITED (IN) | 2013-06-25 | — | — | US | claimed |
| CN-103145628-A | Erlotinib-hydrate crystal form I preparation method | QILU PHARMACEUTICAL CO LTD | 2013-06-12 | — | — | CN | claimed |
| US-20120022256-A1 | Novel Hydrated Form of Erlotinib Free Base and a Process For Preparation Of Erlotinib Hydrochloride Polymorph Form A Substantially Free of Polymorph Form B | HETERO DRUGS LIMITED (IN) | 2012-01-26 | — | — | US | claimed |
| US-20100136116-A1 | NOVEL HYDRATED FORM OF ERLOTINIB FREE BASE AND A PROCESS FOR PREPARATION OF ERLOTINIB HYDROCHLORIDE POLYMORPH FORM A SUBSTANTIALLY FREE OF POLYMORPH FORM B | HETERO DRUGS LIMITED (IN) | 2010-06-03 | — | — | US | claimed |
| EP-2176241-A2 | A NOVEL HYDRATED FORM OF ERLOTINIB FREE BASE AND A PROCESS FOR PREPARATION OF ERLOTINIB HYDROCHLORIDE POLYMORPH FORM A SUBSTANTIALLY FREE OF POLYMORPH FORM B | Hetero Drugs Limited (IN) | 2010-04-21 | — | — | EP | claimed |
| EP-2054393-A1 | CRYSTALLINE ERLOTINIB | Synthon B.V. (NL) | 2009-05-06 | — | — | EP | claimed |
| WO-2009024989-A2 | A NOVEL HYDRATED FORM OF ERLOTINIB FREE BASE AND A PROCESS FOR PREPARATION OF ERLOTINIB HYDROCHLORIDE POLYMORPH FORM A SUBSTANTIALLY FREE OF POLYMORPH FORM B | HETERO DRUGS LIMITED (IN) | 2009-02-26 | — | — | WO | claimed |
| WO-2008012105-A1 | CRYSTALLINE ERLOTINIB | SYNTHON B.V. (NL) | 2008-01-31 | — | — | WO | claimed |
| EP-1076652-B1 | N-(3-ETHYNYLPHENYLAMINO)-6,7-BIS(2-METHOXYETHOXY)-4-QUINAZOLINAMINE MESYLATE ANHYDRATE AND MONOHYDRATE | OSI PHARM INC (US) | 2005-05-18 | — | — | EP | claimed |
| EP-2176241-B1 | A NOVEL HYDRATED FORM OF ERLOTINIB FREE BASE AND A PROCESS FOR PREPARATION OF ERLOTINIB HYDROCHLORIDE POLYMORPH FORM A SUBSTANTIALLY FREE OF POLYMORPH FORM B | HETERO DRUGS LTD (IN) | 2015-12-23 | — | — | EP | disclosed |
| WO-2014136126-A2 | A PROCESS FOR PREPARING ERLOTINIB HYDROCHLORIDE FORM A | LAURUS LABS PRIVATE LIMITED (IN) | 2014-09-12 | — | — | WO | disclosed |
| US-8669265-B2 | Hydrated form of erlotinib free base and a process for preparation of erlotinib hydrochloride polymorph form a substantially free of polymorph form B | HETERO DRUGS LIMITED (IN) | 2014-03-11 | — | — | US | disclosed |
| US-20130252978-A1 | Novel Hydrated Form of Erlotinib Free Base and a Process For Preparation Of Erlotinib Hydrochloride Polymorph Form A Substantially Free of Polymorph Form B | HETERO RESEARCH FOUNDATION (IN) | 2013-09-26 | — | — | US | disclosed |
| WO-2009024989-A2 | A NOVEL HYDRATED FORM OF ERLOTINIB FREE BASE AND A PROCESS FOR PREPARATION OF ERLOTINIB HYDROCHLORIDE POLYMORPH FORM A SUBSTANTIALLY FREE OF POLYMORPH FORM B | HETERO DRUGS LIMITED (IN) | 2009-02-26 | — | — | WO | disclosed |
| US-20080058355-A1 | CRYSTALLINE ERLOTINIB | SYNTHON BV (NL) | 2008-03-06 | — | — | US | disclosed |
| WO-2008012105-A1 | CRYSTALLINE ERLOTINIB | SYNTHON B.V. (NL) | 2008-01-31 | — | — | WO | disclosed |
| WO-2008012105-A1 | CRYSTALLINE ERLOTINIB | SYNTHON B.V. (NL) | 2008-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058355-A1 | CRYSTALLINE ERLOTINIB | EGFR, TP53, HRAS | EGFR 1/4885ERBB2 12/4885GAK 383/4885 |
| US-20130252978-A1 | Novel Hydrated Form of Erlotinib Free Base and a Process For Preparation Of Erlotinib Hydrochloride Polymorph Form A Substantially Free of Polymorph Form B | KRAS, TP53, EGFR | EGFR 3/4885ERBB2 46/4885GAK 2538/4885 |
| US-20120022256-A1 | Novel Hydrated Form of Erlotinib Free Base and a Process For Preparation Of Erlotinib Hydrochloride Polymorph Form A Substantially Free of Polymorph Form B | KRAS, TP53, EGFR | EGFR 3/4885ERBB2 46/4885GAK 2538/4885 |
| US-20100136116-A1 | NOVEL HYDRATED FORM OF ERLOTINIB FREE BASE AND A PROCESS FOR PREPARATION OF ERLOTINIB HYDROCHLORIDE POLYMORPH FORM A SUBSTANTIALLY FREE OF POLYMORPH FORM B | KRAS, TP53, EGFR | EGFR 3/4885ERBB2 46/4885GAK 2538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.