Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 2/20 | 0.41 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 5/20 | 0.38 |
| ▸ | SPR | P35270 | 3/20 | 0.38 |
| ▸ | KRAS | P01116 | 3/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4183682 | 0.90 | TRPC3 (0.43) | TRPC3TRPC6DRD1RIPK1GRM5 | |
| SCHEMBL3821054 | 0.86 | HTT (0.45) | TRPC3TRPC6RIPK1GRM5LMNA | |
| SCHEMBL3812898 | 0.86 | HTT (0.45) | TRPC3TRPC6RIPK1GRM5LMNA | |
| SCHEMBL3816778 | 0.86 | TRPC3 (0.43) | TRPC3TRPC6DRD1RIPK1GRM5 | |
| SCHEMBL3814941 | 0.86 | TRPC3 (0.43) | TRPC3TRPC6DRD1RIPK1GRM5 | |
| SCHEMBL4022777 | 0.84 | TRPC3 (0.42) | TRPC3TRPC6DRD1RIPK1GRM5 | |
| SCHEMBL4025530 | 0.82 | TRPC3 (0.41) | TRPC3TRPC6DRD1RIPK1GRM5 | |
| SCHEMBL3819293 | 0.81 | TRPC3 (0.40) | TRPC3TRPC6DRD1RIPK1GRM5 | |
| SCHEMBL3814391 | 0.81 | TRPC3 (0.40) | TRPC3TRPC6DRD1RIPK1GRM5 | |
| SCHEMBL3816775 | 0.79 | TRPC3 (0.44) | TRPC3TRPC6DRD1RIPK1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |