Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.66 |
| ▸ | HPGD | P15428 | 6/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | GLA | P06280 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 5/20 | 0.54 |
| ▸ | CA12 | O43570 | 4/20 | 0.54 |
| ▸ | CA1 | P00915 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19113721 | 0.86 | KDM4E (0.68) | KDM4EALDH1A1HPGDKMT2AHSD17B10 | |
| SCHEMBL19649026 | 0.86 | KDM4E (0.68) | KDM4EALDH1A1HPGDKMT2AHSD17B10 | |
| SCHEMBL10382290 | 0.85 | KDM4E (0.80) | KDM4EALDH1A1HPGDKMT2AHSD17B10 | |
| SCHEMBL4182396 | 0.84 | CA9 (0.52) | KDM4EALDH1A1HPGDKMT2AHSD17B10 | |
| SCHEMBL18800098 | 0.84 | KDM4E (0.66) | KDM4EALDH1A1HPGDKMT2AHSD17B10 | |
| SCHEMBL11905579 | 0.83 | CA9 (0.51) | KDM4EALDH1A1HPGDKMT2AHSD17B10 | |
| SCHEMBL11905589 | 0.83 | CA9 (0.51) | KDM4EALDH1A1HPGDKMT2AHSD17B10 | |
| SCHEMBL30454435 | 0.83 | CA9 (0.51) | KDM4EALDH1A1HPGDKMT2AHSD17B10 | |
| SCHEMBL10381150 | 0.83 | KDM4E (0.71) | KDM4EALDH1A1HPGDKMT2AHSD17B10 | |
| SCHEMBL14974877 | 0.83 | KDM4E (0.77) | KDM4EALDH1A1HPGDKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9540317-B2 | Class- and isoform-specific HDAC inhibitors and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-01-10 | — | — | US | disclosed |
| US-20090136979-A1 | Class IIA Histone Deacetylase (HDAC) Substrate | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANG (IT) | 2009-05-28 | — | — | US | disclosed |