Dezaguanine

Dezaguanine

SCHEMBL4184

Nc1cc2[nH]cnc2c(=O)[nH]1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PNP P00491 4/20 1.00
ABL1 P00519 1/20 0.44
RIN1 Q13671 1/20 0.44
PARP1 P09874 4/20 0.40
MAPT P10636 3/20 0.38
ALDH1A1 P00352 2/20 0.38
KDM4E B2RXH2 2/20 0.38
APEX1 P27695 1/20 0.38
RECQL P46063 1/20 0.38
BLM P54132 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
QTRT1 Q9BXR0 1/20 0.36
PRKCI P41743 1/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
PRNP P04156 1/20 0.36
HPGD P15428 1/20 0.36
HTT P42858 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
BCL2 P10415 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dezaguanine SCHEMBL19439015 0.89 PNP (0.79) PNPABL1RIN1PARP1MAPT
Dezaguanine SCHEMBL4251 0.89 PNP (0.79) PNPABL1RIN1PARP1MAPT
Dezaguanine SCHEMBL10911163 0.86 PNP (0.74) PNPABL1RIN1PARP1MAPT
SCHEMBL13663973 0.77 PNP (0.62) PNPPARP1MAPTALDH1A1KDM4E
SCHEMBL11123356 0.69 PNP (0.53) PNPABL1PARP1ALDH1A1KDM4E
Dezaguanine SCHEMBL29384550 0.69 PNP (0.53) PNPABL1RIN1PARP1MAPT
SCHEMBL21896049 0.69 PNP (0.53) PNPABL1RIN1PARP1MAPT
SCHEMBL16303465 0.68 PNP (0.51) PNPPARP1MAPTKDM4EBLM
SCHEMBL30985967 0.67 PNP (0.50) PNPABL1RIN1PARP1MAPT
SCHEMBL28871076 0.65 PNP (0.48) PNPPARP1MAPTALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 27147 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12630827-B2 Antisense oligonucleotides targeting SCN2A for the treatment of SCN1A encephalopathies ROGCON, INC. (US) 2026-05-19 US claimed
US-20260116861-A1 ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-04-30 US claimed
US-12522572-B2 Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-01-13 US claimed
US-20250257360-A1 OLIGONUCLEOTIDE INTERFERENCE TREATMENTS OF PROSTATE CANCER UNIV OKLAHOMA (US) 2025-08-14 US claimed
CN-113151261-B Antisense oligonucleotides as inhibitors of TGF-R signaling 神经视觉医药有限公司 2025-06-17 CN claimed
US-20250179503-A1 METHODS OF USING OLIGOMERIC COMPOUNDS TO TREAT SCN2A-RELATED DISORDERS PRAXIS PREC MEDICINES INC (US) 2025-06-05 US claimed
US-20250146073-A1 METHODS FOR THE TREATMENT OF SCN2A-RELATED DISORDERS PRAXIS PREC MEDICINES INC (US) 2025-05-08 US claimed
EP-4524131-A1 SMALL MOLECULES FOR TREATING CANCER, INHABITING CHEMOKINE ACTIVITY AND/OR INDUCING CELL DEATH AlonBio Ltd. (IL) 2025-03-19 EP claimed
US-20250066799-A1 UNNATURAL BASE PAIR COMPOSITIONS AND METHODS OF USE THE SCRIPPS RESEARCH INSTITUTE 2025-02-27 US claimed
WO-2025041085-A1 DUAL NUCLEASE SYSTEMS FOR GENE EDITING, METHODS OF PRODUCING AND USING SAME SPECIFIC BIOLOGICS INC. (CA) 2025-02-27 WO claimed
EP-0418309-A1 OLIGONUCLEOTIDE ANALOGS CONTAINING SULFUR BENNER, Steven Albert (CH) 1991-03-27 EP claimed
EP-0393575-A1 Neoplasia treatment compositions containing antineoplastic agent and side-effect reducing protective agent G.D. Searle & Co. (US) 1990-10-24 EP claimed
WO-1989012060-A1 OLIGONUCLEOTIDE ANALOGS CONTAINING SULFUR BENNER STEVEN ALBERT (CH) 1989-12-14 WO claimed
EP-0224283-A2 Brain-specific drug delivery UNIVERSITY OF FLORIDA (US) 1987-06-03 EP claimed
EP-0222425-A2 Brain-specific drug delivery UNIVERSITY OF FLORIDA (US) 1987-05-20 EP claimed
EP-0218300-A2 Brain-specific drug delivery UNIVERSITY OF FLORIDA (US) 1987-04-15 EP claimed
EP-0103417-B1 3-DEAZAGUANINE SULPHONIC ACID SALTS WARNER-LAMBERT COMPANY (US) 1986-10-29 EP claimed
EP-0110955-A1 BRAIN-SPECIFIC DRUG DELIVERY. UNIV FLORIDA (US) 1984-06-20 EP claimed
EP-0103417-A1 3-Deazaguanine sulphonic acid salts WARNER-LAMBERT COMPANY (US) 1984-03-21 EP claimed
WO-1983003968-A1 BRAIN-SPECIFIC DRUG DELIVERY UNIVERSITY OF FLORIDA (US) 1983-11-24 WO claimed