Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.42 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.34 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3814958 | 0.91 | PARP1 (0.44) | PARP1GRM5DRD1OPRK1HTR2A | |
| SCHEMBL4024373 | 0.91 | PARP1 (0.44) | PARP1GRM5DRD1OPRK1HTR2A | |
| SCHEMBL3816530 | 0.87 | TP53 (0.39) | DRD1ALDH1A1KDM4ENPC1POLB | |
| SCHEMBL3821156 | 0.85 | DRD1 (0.39) | PARP1GRM5RIPK1DRD1HTR2A | |
| SCHEMBL3824223 | 0.84 | DRD1 (0.49) | PARP1GRM5RIPK1DRD1TRPC3 | |
| SCHEMBL8012792 | 0.84 | DRD1 (0.49) | PARP1GRM5RIPK1DRD1TRPC3 | |
| SCHEMBL3812114 | 0.84 | DRD1 (0.49) | PARP1GRM5RIPK1DRD1TRPC3 | |
| SCHEMBL3816607 | 0.83 | KMT2A (0.42) | PARP1GRM5DRD1TRPC3TRPC6 | |
| SCHEMBL3816636 | 0.82 | KMT2A (0.41) | PARP1GRM5DRD1KMT2AMEN1 | |
| SCHEMBL4173155 | 0.81 | PARP1 (0.42) | PARP1GRM5HTR2AHTR2CKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |