Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 15/20 | 0.51 |
| ▸ | PDE4A | P27815 | 14/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4929250 | 0.85 | PDE4A (0.51) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL3609369 | 0.84 | PDE4B (0.51) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL3604634 | 0.83 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL3598818 | 0.83 | PDE4A (0.48) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL3613653 | 0.81 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL5438839 | 0.81 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL3611279 | 0.81 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL8268120 | 0.81 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL3595738 | 0.80 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL13343011 | 0.80 | PDE4D (0.55) | PDE4DPDE4APDE4BPDE4CPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221661-A1 | PHOSPHODIESTERASE 4 INHIBITORS | HOPPER ALLEN | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221661-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE4B, PDE12 | PDE4D 6/4885PDE4A 1/4885PDE4B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.