Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 10/20 | 0.44 |
| ▸ | CNR1 | P21554 | 8/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.40 |
| ▸ | ABHD12 | Q8N2K0 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13929102 | 1.00 | MEN1 (0.46) | MEN1ALDH1A1KMT2ASGMS2CNR2 | |
| SCHEMBL4195487 | 0.92 | MEN1 (0.42) | MEN1ALDH1A1KMT2ASGMS2CNR2 | |
| SCHEMBL13929097 | 0.92 | MEN1 (0.42) | MEN1ALDH1A1KMT2ASGMS2CNR2 | |
| SCHEMBL4184526 | 0.92 | MEN1 (0.41) | MEN1ALDH1A1KMT2ASGMS2CNR2 | |
| SCHEMBL13929099 | 0.92 | MEN1 (0.41) | MEN1ALDH1A1KMT2ASGMS2CNR2 | |
| SCHEMBL13929104 | 0.91 | PDE4B (0.46) | MEN1ALDH1A1KMT2ASGMS2CNR2 | |
| SCHEMBL4193018 | 0.91 | PDE4B (0.46) | MEN1ALDH1A1KMT2ASGMS2CNR2 | |
| SCHEMBL8299139 | 0.87 | MEN1 (0.39) | MEN1ALDH1A1KMT2ASGMS2CNR2 | |
| SCHEMBL4186392 | 0.86 | PDE4B (0.43) | CNR2CNR1PDE4BPDE4APDE4D | |
| SCHEMBL13929027 | 0.86 | PDE4B (0.43) | CNR2CNR1PDE4BPDE4APDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090035313-A1 | Compounds | PFIZER INC. | 2009-02-05 | — | — | US | disclosed |
| EP-1651640-B1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LTD (GB) | 2007-02-14 | — | — | EP | disclosed |
| US-20060178408-A1 | Nicotinamide derivatives useful as pde4 inhibitors | BARBER CHRISTOPHER G | 2006-08-10 | — | — | US | disclosed |
| US-20050043326-A1 | Compounds | PFIZER INC | 2005-02-24 | — | — | US | disclosed |
| US-20050020611-A1 | Compounds | PFIZER INC. | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020611-A1 | Compounds | NQO1, NAMPT, NNT | MEN1 532/4885ALDH1A1 212/4885KMT2A 2721/4885 |
| US-20060178408-A1 | Nicotinamide derivatives useful as pde4 inhibitors | PDE4A, PDE4B, PDE4C | MEN1 1891/4885ALDH1A1 356/4885KMT2A 2009/4885 |
| US-20090035313-A1 | Compounds | NQO1, NAMPT, NNT | MEN1 532/4885ALDH1A1 212/4885KMT2A 2721/4885 |
| US-20050043326-A1 | Compounds | NQO1, NAMPT, NNT | MEN1 532/4885ALDH1A1 212/4885KMT2A 2721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.