Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3480013 | 0.91 | MAPT (0.50) | MAPK1MAPTMEN1KMT2ATDP1 | |
| SCHEMBL3479715 | 0.90 | KMT2A (0.50) | MAPTMEN1KMT2ATDP1L3MBTL1 | |
| SCHEMBL3480189 | 0.89 | MEN1 (0.51) | MAPTMEN1KMT2ATDP1L3MBTL1 | |
| SCHEMBL4188130 | 0.88 | MEN1 (0.47) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2419841 | 0.85 | MAPK1 (0.49) | MAPK1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL2421192 | 0.84 | MEN1 (0.49) | MAPK1MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2422685 | 0.83 | KMT2A (0.49) | MAPK1MAPTMEN1KMT2ATDP1 | |
| SCHEMBL2419239 | 0.83 | MAPT (0.48) | MAPK1MAPTMEN1KMT2ATDP1 | |
| SCHEMBL2421112 | 0.83 | KMT2A (0.51) | MAPK1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL2426626 | 0.83 | MEN1 (0.56) | MAPTMEN1KMT2ATDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2026802-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | Laboratoires Serono SA (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007141224-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | LABORATOIRES SERONO SA (CH) | 2007-12-13 | — | — | WO | disclosed |