Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.37 |
| ▸ | PDE4A | P27815 | 5/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4180651 | 0.78 | PDE4B (0.44) | PDE4BGAAMAPK1TSHRPDE4D | |
| SCHEMBL3607474 | 0.78 | PDE4B (0.42) | PDE4BGAAMAPK1TSHRPDE4D | |
| SCHEMBL4190830 | 0.75 | PDE4B (0.45) | PDE4BGAAMAPK1TSHRPDE4D | |
| SCHEMBL3596979 | 0.74 | PDE4B (0.44) | PDE4BGAAMAPK1TSHRPDE4D | |
| SCHEMBL3604579 | 0.73 | PDE4B (0.44) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL5793483 | 0.71 | PDE4B (0.43) | PDE4BPDE4DPDE4APDE4CPI4KB | |
| SCHEMBL3605765 | 0.71 | PDE4B (0.43) | PDE4BPDE4DPDE4APDE4CPI4KB | |
| SCHEMBL3600833 | 0.71 | PDE4B (0.44) | PDE4BGAAMAPK1TSHRPDE4D | |
| SCHEMBL3608923 | 0.70 | PDE4B (0.46) | PDE4BPDE4DPDE4APDE4CALDH1A1 | |
| SCHEMBL3610448 | 0.69 | PDE4B (0.45) | PDE4BGAAMAPK1TSHRPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221661-A1 | PHOSPHODIESTERASE 4 INHIBITORS | HOPPER ALLEN | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221661-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE4B, PDE12 | PDE4B 2/4885GAA 1258/4885MAPK1 2203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.