Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.77 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.72 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.60 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18359138 | 0.90 | EGFR (0.80) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL7058784 | 0.88 | EGFR (0.80) | EGFRERBB2ERBB4 | |
| SCHEMBL2991352 | 0.87 | EGFR (1.00) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL2991982 | 0.86 | EGFR (1.00) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL2991983 | 0.86 | EGFR (1.00) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL2994145 | 0.86 | EGFR (1.00) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL2991995 | 0.85 | EGFR (1.00) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL2991992 | 0.85 | EGFR (1.00) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL2996888 | 0.84 | EGFR (1.00) | EGFRERBB2ERBB4MEN1KMT2A | |
| SCHEMBL18359137 | 0.83 | EGFR (0.68) | EGFRERBB2ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892789-B2 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER LAMBERT CO (US) | 2009-11-18 | — | — | EP | disclosed |
| EP-0892789-B1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER LAMBERT CO (US) | 2002-02-27 | — | — | EP | disclosed |