Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 5/20 | 0.59 |
| ▸ | CNR2 | P34972 | 11/20 | 0.58 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.54 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4186644 | 0.90 | PDE4B (0.51) | CNR1CNR2 | |
| SCHEMBL4913629 | 0.88 | CNR1 (0.49) | CNR1CNR2KDM4EMEN1MAPT | |
| SCHEMBL923180 | 0.87 | CNR2 (0.71) | CNR1CNR2 | |
| SCHEMBL29838956 | 0.87 | CNR2 (0.71) | CNR1CNR2 | |
| SCHEMBL5769070 | 0.87 | KDM4E (0.58) | CNR1CNR2GABRA2GABRB2KDM4E | |
| SCHEMBL923308 | 0.87 | CNR1 (0.63) | CNR1CNR2GABRA2GABRB2KDM4E | |
| SCHEMBL972368 | 0.86 | CNR1 (0.62) | CNR1CNR2GABRA2GABRB2KDM4E | |
| SCHEMBL4632916 | 0.85 | CNR1 (0.59) | CNR1CNR2GABRA2GABRB2KDM4E | |
| SCHEMBL17163901 | 0.85 | CNR2 (0.62) | CNR1CNR2GABRA2GABRB2KDM4E | |
| SCHEMBL923181 | 0.85 | CNR1 (0.61) | CNR1CNR2GABRA2GABRB2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015155566-A1 | FUSED PYRAZOLE COMPOUNDS AS CB1R ANTAGONISTS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2015-10-15 | — | — | WO | disclosed |
| WO-2009095752-A1 | FUSED PYRAZOLE DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (US) | 2009-08-06 | — | — | WO | disclosed |