Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.83 |
| ▸ | MTOR | P42345 | 20/20 | 0.83 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4170362 | 0.93 | PIK3CA (0.87) | PIK3CAMTORPIK3CD | |
| SCHEMBL4181215 | 0.92 | PIK3CA (0.82) | PIK3CAMTORPIK3CD | |
| SCHEMBL7876645 | 0.92 | PIK3CA (0.85) | PIK3CAMTORPIK3CD | |
| SCHEMBL4170322 | 0.91 | PIK3CA (1.00) | PIK3CAMTORPIK3CD | |
| SCHEMBL4183872 | 0.90 | PIK3CA (0.85) | PIK3CAMTORPIK3CD | |
| SCHEMBL4173217 | 0.89 | MTOR (0.79) | PIK3CAMTORPIK3CD | |
| SCHEMBL4180309 | 0.89 | PIK3CA (1.00) | PIK3CAMTORPIK3CD | |
| SCHEMBL4187812 | 0.88 | PIK3CA (0.75) | PIK3CAMTORPIK3CD | |
| SCHEMBL4185067 | 0.88 | PIK3CA (1.00) | PIK3CAMTOR | |
| Trifluoroacetic Acid SCHEMBL4182876 | 0.86 | PIK3CA (0.94) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009097490-A1 | 1H-PYRAZOLO[3,4-D]PYRIMIDINE, PURINE, 7H-PURIN-8(9H)-ONE, 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE, AND THIENO[3,2-D]PYRIMIDINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-08-06 | — | — | WO | claimed |
| WO-2009097490-A1 | 1H-PYRAZOLO[3,4-D]PYRIMIDINE, PURINE, 7H-PURIN-8(9H)-ONE, 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE, AND THIENO[3,2-D]PYRIMIDINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-08-06 | — | — | WO | disclosed |