Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCARB1 | Q8WTV0 | 7/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RORC | P51449 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030252 | 0.90 | SCARB1 (0.70) | SCARB1HSD17B10NPC1RORCHDAC1 | |
| SCHEMBL4028758 | 0.89 | SCARB1 (0.72) | SCARB1HSD17B10NPC1RORCHDAC1 | |
| SCHEMBL4024931 | 0.89 | SCARB1 (0.69) | SCARB1HSD17B10NPC1RORCHDAC1 | |
| SCHEMBL4195549 | 0.88 | SCARB1 (0.68) | SCARB1HSD17B10NPC1RORCHDAC1 | |
| SCHEMBL4029504 | 0.88 | SCARB1 (0.68) | SCARB1HSD17B10NPC1RORCHDAC1 | |
| SCHEMBL13746723 | 0.86 | SCARB1 (0.64) | SCARB1HSD17B10NPC1RORCHDAC1 | |
| SCHEMBL4028396 | 0.86 | SCARB1 (0.66) | SCARB1HSD17B10NPC1RORCHDAC1 | |
| SCHEMBL6756508 | 0.85 | SCARB1 (0.63) | SCARB1HSD17B10NPC1RORCHDAC1 | |
| SCHEMBL4199326 | 0.84 | SCARB1 (0.63) | SCARB1HSD17B10NPC1RORCHDAC1 | |
| SCHEMBL4188561 | 0.83 | SCARB1 (0.67) | SCARB1HSD17B10NPC1RORCPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |