Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 1/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | RHOC | P08134 | 1/20 | 0.47 |
| ▸ | RHOA | P61586 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.43 |
| ▸ | TGM2 | P21980 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | USP5 | P45974 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2421312 | 1.00 | MAPK9 (0.57) | MAPK9MAPK10MEN1KMT2ARHOC | |
| SCHEMBL1518918 | 0.94 | MAPK9 (0.62) | MAPK9MAPK10MEN1KMT2ATP53 | |
| SCHEMBL2424312 | 0.91 | MAPK9 (0.55) | MAPK9MAPK10MEN1KMT2ARHOC | |
| SCHEMBL2422247 | 0.91 | MAPK9 (0.54) | MAPK9MAPK10MEN1KMT2ARHOC | |
| SCHEMBL2420588 | 0.90 | MAPK9 (0.59) | MAPK9MAPK10MEN1KMT2ATP53 | |
| SCHEMBL2426728 | 0.90 | MAPK9 (0.58) | MAPK9MAPK10MEN1KMT2ATP53 | |
| SCHEMBL1518791 | 0.89 | MAPK9 (0.64) | MAPK9MAPK10MEN1KMT2ATP53 | |
| SCHEMBL6431692 | 0.89 | MEN1 (0.62) | MAPK9MAPK10MEN1KMT2ATP53 | |
| SCHEMBL3480493 | 0.89 | MAPK9 (0.56) | MAPK9MAPK10MEN1KMT2ATRPV4 | |
| SCHEMBL3480150 | 0.89 | MAPK9 (0.56) | MAPK9MAPK10MEN1KMT2ATGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2026802-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | Laboratoires Serono SA (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007141224-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | LABORATOIRES SERONO SA (CH) | 2007-12-13 | — | — | WO | disclosed |