Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 6/20 | 0.57 |
| ▸ | RBPJ | Q06330 | 2/20 | 0.57 |
| ▸ | NOTCH3 | Q9UM47 | 4/20 | 0.56 |
| ▸ | CCKBR | P32239 | 5/20 | 0.55 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.53 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.53 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.53 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.53 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.53 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4189269 | 1.00 | NOTCH1 (0.57) | NOTCH1RBPJNOTCH3CCKBRPSEN1 | |
| SCHEMBL4189272 | 1.00 | NOTCH1 (0.57) | NOTCH1RBPJNOTCH3CCKBRPSEN1 | |
| SCHEMBL3487863 | 0.92 | NOTCH1 (0.62) | NOTCH1RBPJNOTCH3CCKBRPSEN1 | |
| SCHEMBL13434946 | 0.92 | NOTCH1 (0.62) | NOTCH1RBPJNOTCH3CCKBRPSEN1 | |
| SCHEMBL7593327 | 0.91 | NOTCH1 (0.52) | NOTCH1RBPJNOTCH3CCKBRPSEN1 | |
| SCHEMBL4186560 | 0.91 | NOTCH1 (0.52) | NOTCH1RBPJNOTCH3CCKBRPSEN1 | |
| SCHEMBL4186558 | 0.91 | NOTCH1 (0.52) | NOTCH1RBPJNOTCH3CCKBRPSEN1 | |
| SCHEMBL4984439 | 0.91 | NOTCH1 (0.60) | NOTCH1RBPJNOTCH3CCKBRPSEN1 | |
| SCHEMBL4191513 | 0.91 | NOTCH1 (0.60) | NOTCH1RBPJNOTCH3CCKBRPSEN1 | |
| SCHEMBL4191510 | 0.91 | NOTCH1 (0.60) | NOTCH1RBPJNOTCH3CCKBRPSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090111793-A1 | HYDROXYALKANOYLAMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF A BETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2009-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111793-A1 | HYDROXYALKANOYLAMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF A BETA PROTEIN PRODUCTION | APP, BACE1, APH1A | NOTCH1 575/4885RBPJ 2821/4885NOTCH3 1575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.