Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.58 |
| ▸ | KDR | P35968 | 8/20 | 0.51 |
| ▸ | EGFR | P00533 | 4/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.47 |
| ▸ | STK10 | O94804 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | YES1 | P07947 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | BCR | P11274 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.47 |
| ▸ | WEE1 | P30291 | 1/20 | 0.47 |
| ▸ | ABL2 | P42684 | 1/20 | 0.47 |
| ▸ | NEK3 | P51956 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4342995 | 0.83 | KDR (0.51) | KDREGFRERBB2STK10MAP4K4 | |
| SCHEMBL21408869 | 0.83 | KIT (0.61) | KITKDRTBK1CSF1R | |
| SCHEMBL3848752 | 0.80 | KDR (0.72) | KITKDREGFRERBB2STK10 | |
| SCHEMBL20305787 | 0.78 | KIT (0.55) | KITKDREGFRERBB2STK10 | |
| SCHEMBL4726959 | 0.75 | EGFR (0.66) | EGFRCSF1R | |
| SCHEMBL4726940 | 0.75 | EGFR (0.52) | KITKDREGFRERBB2CSF1R | |
| SCHEMBL29814489 | 0.75 | KIT (0.53) | KITKDRTBK1CSF1R | |
| SCHEMBL27003844 | 0.75 | KIT (0.53) | KITKDRTBK1CSF1R | |
| SCHEMBL15689394 | 0.74 | KIT (1.00) | KITCSF1R | |
| SCHEMBL15526000 | 0.73 | BTK (0.53) | KITKDRTBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247548-A1 | PYRROLOPYRIMIDINE DERIVATIVES FOR TREATING PROLIFERATIVE DISEASES | CARAVATTI GIORGIO | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247548-A1 | PYRROLOPYRIMIDINE DERIVATIVES FOR TREATING PROLIFERATIVE DISEASES | CCNO, CCNI, CCNA1 | KIT 2162/4885KDR 3118/4885EGFR 2275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.