Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND3 | P30281 | 12/20 | 0.47 |
| ▸ | CDK4 | P11802 | 11/20 | 0.47 |
| ▸ | CCND1 | P24385 | 11/20 | 0.47 |
| ▸ | CCND2 | P30279 | 11/20 | 0.47 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.46 |
| ▸ | MARK3 | P27448 | 1/20 | 0.46 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.46 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.46 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.46 |
| ▸ | MARK1 | Q9P0L2 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | WEE1 | P30291 | 5/20 | 0.44 |
| ▸ | CCNK | O75909 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4202387 | 0.84 | STAT6 (0.53) | CCND3CDK4CCND1CCND2LCK | |
| SCHEMBL4191368 | 0.82 | CCND3 (0.47) | CCND3CDK4CCND1CCND2NUAK1 | |
| SCHEMBL4186979 | 0.82 | CDK4 (0.51) | CCND3CDK4CCND1CCND2WEE1 | |
| SCHEMBL4191957 | 0.78 | CDK4 (0.49) | CCND3CDK4CCND1CCND2WEE1 | |
| SCHEMBL4195626 | 0.77 | WEE1 (0.48) | CCND3CDK4CCND1CCND2WEE1 | |
| SCHEMBL4189759 | 0.76 | CDK4 (0.46) | CCND3CDK4CCND1CCND2WEE1 | |
| SCHEMBL4191584 | 0.74 | CDK4 (0.45) | CCND3CDK4CCND1CCND2WEE1 | |
| SCHEMBL4191077 | 0.74 | CDK4 (0.44) | CCND3CDK4CCND1CCND2WEE1 | |
| SCHEMBL4193743 | 0.73 | CDK4 (0.43) | CCND3CDK4CCND1CCND2WEE1 | |
| SCHEMBL4186974 | 0.73 | CDK4 (0.48) | CCND3CDK4CCND1CCND2WEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029145-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | Novartis Ag (CH) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007140222-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2007-12-06 | — | — | WO | disclosed |