Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.65 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 2/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.53 |
| ▸ | FBP1 | P09467 | 2/20 | 0.53 |
| ▸ | INSR | P06213 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.53 |
| ▸ | TEK | Q02763 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4032038 | 0.87 | EGFR (0.68) | EGFRGRM1DYRK1AAURKAERBB2 | |
| SCHEMBL23950086 | 0.85 | EGFR (0.66) | EGFRGRM1DYRK1AAURKAERBB2 | |
| SCHEMBL8311292 | 0.80 | EGFR (0.77) | EGFRGRM1AURKAERBB2FBP1 | |
| SCHEMBL9902104 | 0.79 | EGFR (0.58) | EGFRGRM1DYRK1AAURKAERBB2 | |
| SCHEMBL1734685 | 0.79 | EGFR (1.00) | EGFRGRM1AURKAERBB2FBP1 | |
| SCHEMBL30301821 | 0.79 | EGFR (1.00) | EGFRGRM1AURKAERBB2FBP1 | |
| SCHEMBL2989951 | 0.79 | EGFR (0.75) | EGFRGRM1AURKAERBB2FBP1 | |
| SCHEMBL2991661 | 0.79 | EGFR (0.75) | EGFRGRM1AURKAERBB2FBP1 | |
| SCHEMBL3525606 | 0.78 | EGFR (0.62) | EGFRGRM1DYRK1AAURKAERBB2 | |
| SCHEMBL3060241 | 0.78 | EGFR (0.55) | EGFRGRM1DYRK1AAURKAERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892789-B2 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER LAMBERT CO (US) | 2009-11-18 | — | — | EP | disclosed |
| EP-0892789-B1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER LAMBERT CO (US) | 2002-02-27 | — | — | EP | disclosed |