Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.69 |
| ▸ | FYN | P06241 | 1/20 | 0.69 |
| ▸ | SRC | P12931 | 1/20 | 0.69 |
| ▸ | BLK | P51451 | 1/20 | 0.69 |
| ▸ | BMX | P51813 | 1/20 | 0.69 |
| ▸ | JAK3 | P52333 | 1/20 | 0.69 |
| ▸ | BTK | Q06187 | 1/20 | 0.69 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.69 |
| ▸ | FBP1 | P09467 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4187418 | 0.92 | EGFR (0.69) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL8434638 | 0.87 | EGFR (0.64) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL8430947 | 0.87 | EGFR (0.64) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL2990711 | 0.83 | EGFR (0.72) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL8430949 | 0.82 | EGFR (0.60) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL2680536 | 0.82 | EGFR (1.00) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL8150558 | 0.82 | EGFR (0.76) | EGFRERBB2FYNSRCJAK3 | |
| SCHEMBL29359583 | 0.82 | EGFR (1.00) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL3663489 | 0.81 | EGFR (1.00) | EGFRERBB2SRCERBB4FBP1 | |
| SCHEMBL2995335 | 0.80 | EGFR (0.80) | EGFRERBB2FYNSRCBLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892789-B2 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER LAMBERT CO (US) | 2009-11-18 | — | — | EP | claimed |
| EP-0892789-B1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER LAMBERT CO (US) | 2002-02-27 | — | — | EP | claimed |