Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 17/20 | 0.52 |
| ▸ | CDK1 | P06493 | 6/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.51 |
| ▸ | CDK4 | P11802 | 3/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.50 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.50 |
| ▸ | CCND1 | P24385 | 1/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.50 |
| ▸ | CCND3 | P30281 | 1/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.50 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | CDK7 | P50613 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | CCNH | P51946 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4509148 | 0.87 | IKBKB (0.58) | CDK2CDK1KCNH2CDK4CCNT1 | |
| SCHEMBL4504958 | 0.87 | KCNH2 (0.65) | CDK2CDK1KCNH2CDK4CCNT1 | |
| SCHEMBL4496420 | 0.85 | KCNH2 (0.52) | CDK2CDK1KCNH2CDK4CCNT1 | |
| SCHEMBL4515012 | 0.84 | KCNH2 (0.53) | CDK2CDK1KCNH2CDK4CCNT1 | |
| SCHEMBL4510051 | 0.83 | KCNH2 (0.61) | CDK2CDK1KCNH2CDK4CCNT1 | |
| SCHEMBL4494683 | 0.83 | KCNH2 (0.54) | CDK2CDK1KCNH2CDK4CCNT1 | |
| SCHEMBL4502015 | 0.82 | CDK2 (0.54) | CDK2CDK1KCNH2CDK4CCNT1 | |
| SCHEMBL4205173 | 0.82 | CDK2 (0.55) | CDK2CDK1KCNH2CDK4CCNT1 | |
| SCHEMBL4517599 | 0.82 | CDK2 (0.56) | CDK2CDK1KCNH2CDK4CCNT1 | |
| SCHEMBL4504031 | 0.82 | CDK2 (0.66) | CDK2CDK1KCNH2CDK4CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032559-A1 | 2-HETEROCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007138268-A1 | 2-HETEROCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2007-12-06 | — | — | WO | disclosed |