Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.64 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.45 |
| ▸ | VHL | P40337 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | QPCT | Q16769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5473528 | 0.86 | GRM5 (0.70) | GRM5CYP2A6IRAK4 | |
| SCHEMBL5205462 | 0.84 | GRM5 (0.58) | GRM5CYP2A6MEN1 | |
| SCHEMBL5202470 | 0.81 | GRM5 (0.67) | GRM5CYP19A1IRAK4FYN | |
| SCHEMBL5204644 | 0.78 | GRM5 (1.00) | GRM5CYP1A2CYP3A4 | |
| SCHEMBL5792876 | 0.77 | CYP2A6 (0.48) | GRM5CYP2A6VHLMEN1PSIP1 | |
| SCHEMBL19670662 | 0.77 | CYP2A6 (0.76) | GRM5CYP2A6MEN1PSIP1AXL | |
| SCHEMBL5204260 | 0.76 | GRM5 (0.54) | GRM5CYP11B1CYP11B2 | |
| SCHEMBL5469881 | 0.75 | MIF (0.49) | GRM5CYP2A6VHLMEN1PSIP1 | |
| SCHEMBL24492855 | 0.75 | CYP2A6 (0.73) | GRM5CYP2A6MEN1PSIP1AXL | |
| SCHEMBL11965543 | 0.75 | CYP2A6 (0.73) | GRM5CYP2A6MEN1PSIP1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100537564-C | Di-aryl substituted triazole modulators of metabotropic glutamate receptor-5 | MERCK & CO INC (US) | 2009-09-09 | — | — | CN | claimed |
| EP-1613617-A4 | DI-ARYL SUBSTITUTED TRIAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO INC (US) | 2009-02-18 | — | — | EP | claimed |
| US-7268151-B2 | Di-aryl substituted triazole modulators of metabotropic glutamate receptor-5 | MERCK & CO., INC. (US) | 2007-09-11 | — | — | US | claimed |
| US-20070082067-A1 | Di-aryl substituted triazole modulators of metabotropic glutamate receptor-5 | MERCK SHARP & DOHME CORP. | 2007-04-12 | — | — | US | claimed |
| CN-1795186-A | Di-aryl substituted triazole modulators of metabotropic glutamate receptor-5 | MERCK & CO INC (US) | 2006-06-28 | — | — | CN | claimed |
| EP-1613617-A2 | DI-ARYL SUBSTITUTED TRIAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | Merck & Co., Inc. (US) | 2006-01-11 | — | — | EP | claimed |
| WO-2004089306-A2 | DI-ARYL SUBSTITUTED TRIAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO., INC. (US) | 2004-10-21 | — | — | WO | claimed |
| US-7268151-B2 | Di-aryl substituted triazole modulators of metabotropic glutamate receptor-5 | MERCK & CO., INC. (US) | 2007-09-11 | — | — | US | disclosed |
| US-7268151-B2 | Di-aryl substituted triazole modulators of metabotropic glutamate receptor-5 | MERCK & CO., INC. (US) | 2007-09-11 | — | — | US | disclosed |
| US-7268151-B2 | Di-aryl substituted triazole modulators of metabotropic glutamate receptor-5 | MERCK & CO., INC. (US) | 2007-09-11 | — | — | US | disclosed |
| US-20070082067-A1 | Di-aryl substituted triazole modulators of metabotropic glutamate receptor-5 | MERCK SHARP & DOHME CORP. | 2007-04-12 | — | — | US | disclosed |
| US-20070082067-A1 | Di-aryl substituted triazole modulators of metabotropic glutamate receptor-5 | MERCK SHARP & DOHME CORP. | 2007-04-12 | — | — | US | disclosed |
| US-20070082067-A1 | Di-aryl substituted triazole modulators of metabotropic glutamate receptor-5 | MERCK SHARP & DOHME CORP. | 2007-04-12 | — | — | US | disclosed |
| WO-2004089306-A2 | DI-ARYL SUBSTITUTED TRIAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO., INC. (US) | 2004-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082067-A1 | Di-aryl substituted triazole modulators of metabotropic glutamate receptor-5 | GRM5, GRM1, GRIA3 | GRM5 1/4885CYP2A6 1080/4885VHL 3331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.