Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 9/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.56 |
| ▸ | EGFR | P00533 | 3/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.52 |
| ▸ | JAK2 | O60674 | 4/20 | 0.49 |
| ▸ | SYK | P43405 | 3/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | WEE1 | P30291 | 5/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.47 |
| ▸ | BTK | Q06187 | 4/20 | 0.47 |
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.47 |
| ▸ | PAK4 | O96013 | 3/20 | 0.47 |
| ▸ | LCK | P06239 | 3/20 | 0.47 |
| ▸ | FYN | P06241 | 3/20 | 0.47 |
| ▸ | CSF1R | P07333 | 3/20 | 0.47 |
| ▸ | RET | P07949 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4198251 | 0.93 | EGFR (0.59) | PDGFRAPDGFRBEGFRFGFR1JAK2 | |
| SCHEMBL3280136 | 0.87 | EGFR (0.71) | PDGFRAPDGFRBEGFRFGFR1JAK2 | |
| SCHEMBL3283903 | 0.86 | PDGFRA (0.68) | PDGFRAPDGFRBEGFRFGFR1JAK2 | |
| SCHEMBL3286821 | 0.85 | SYK (0.69) | PDGFRAPDGFRBEGFRFGFR1JAK2 | |
| SCHEMBL3279455 | 0.85 | EGFR (0.57) | PDGFRAPDGFRBEGFRFGFR1JAK2 | |
| SCHEMBL3279981 | 0.84 | PDGFRB (0.56) | PDGFRAPDGFRBEGFRFGFR1JAK2 | |
| SCHEMBL3278287 | 0.81 | CDC7 (0.52) | PDGFRAPDGFRBEGFRFGFR1JAK2 | |
| SCHEMBL3280654 | 0.79 | EGFR (0.62) | PDGFRAPDGFRBEGFRFGFR1JAK2 | |
| SCHEMBL3281334 | 0.78 | EGFR (0.61) | PDGFRAPDGFRBEGFRFGFR1JAK2 | |
| SCHEMBL1021471 | 0.78 | PTK2 (0.47) | EGFRJAK2SYKBRD4PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026107-A1 | PROTEIN KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-02-26 | — | — | WO | claimed |