Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.40 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28464172 | 0.98 | TAAR1 (0.45) | TAAR1HTR2AHMOX1GPR52HSP90AA1 | |
| SCHEMBL13801239 | 0.92 | TAAR1 (0.46) | TAAR1HTR2AHMOX1GPR52 | |
| SCHEMBL98013 | 0.83 | TAAR1 (0.50) | TAAR1HTR2AGPR52PLCG1 | |
| SCHEMBL15583726 | 0.82 | TAAR1 (0.59) | TAAR1HTR2AHMOX1HSP90AA1 | |
| SCHEMBL134452 | 0.82 | TAAR1 (0.59) | TAAR1HTR2AHMOX1HSP90AA1 | |
| SCHEMBL30096319 | 0.82 | TAAR1 (0.59) | TAAR1HTR2AHMOX1HSP90AA1 | |
| SCHEMBL18092526 | 0.80 | CDK1 (0.42) | HTR2ACDK1TSHR | |
| SCHEMBL15065059 | 0.80 | USP2 (0.44) | TAAR1HTR2AHMOX1GPR52 | |
| SCHEMBL96078 | 0.80 | SPHK2 (0.48) | CDK1TSHR | |
| SCHEMBL8078219 | 0.80 | USP2 (0.44) | TAAR1HTR2AHMOX1GPR52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716113-B1 | EP2- RECEPTOR AGONISTS | ASTERAND UK LTD (GB) | 2009-02-25 | — | — | EP | disclosed |
| EP-1716113-A1 | EP2- RECEPTOR AGONISTS | ASTERAND UK LIMITED (GB) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005061449-A1 | EP2 RECEPTOR AGONISTS | PHARMAGENE LABORATORIES LIMITED (GB) | 2005-07-07 | — | — | WO | disclosed |