Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2424942 | 0.93 | MEN1 (0.43) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL3479656 | 0.88 | MAPK9 (0.46) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL2421112 | 0.85 | KMT2A (0.51) | MEN1KMT2AMAPK9MAPK10ALDH1A1 | |
| SCHEMBL2422673 | 0.85 | MEN1 (0.53) | MEN1KMT2AMAPK9MAPK10ALDH1A1 | |
| SCHEMBL4203429 | 0.84 | MEN1 (0.36) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL4188130 | 0.84 | MEN1 (0.47) | MEN1KMT2AMAPK9MAPK10ALDH1A1 | |
| SCHEMBL3479835 | 0.83 | MEN1 (0.46) | MEN1KMT2AMAPK9MAPK10ALDH1A1 | |
| SCHEMBL2425516 | 0.83 | MEN1 (0.54) | MEN1KMT2AMAPK9MAPK10ALDH1A1 | |
| SCHEMBL2421192 | 0.83 | MEN1 (0.49) | MEN1KMT2AMAPK9MAPK10ALDH1A1 | |
| SCHEMBL2428331 | 0.83 | KMT2A (0.51) | MEN1KMT2AMAPK9MAPK10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2026802-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | Laboratoires Serono SA (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007141224-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | LABORATOIRES SERONO SA (CH) | 2007-12-13 | — | — | WO | disclosed |