Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 0.53 |
| ▸ | CDK1 | P06493 | 6/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | JUN | P05412 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4504492 | 0.88 | CDK2 (0.54) | CDK2CDK1KCNH2CDK4CCND1 | |
| SCHEMBL4196303 | 0.84 | CDK2 (0.54) | CDK2CDK1KCNH2CDK4CCND1 | |
| SCHEMBL4352357 | 0.83 | CDK2 (0.51) | CDK2CDK1KCNH2CDK4CCND1 | |
| SCHEMBL4203382 | 0.82 | CDK2 (0.53) | CDK2CDK1KCNH2JUNMAPK8 | |
| SCHEMBL4505228 | 0.81 | CDK2 (0.65) | CDK2CDK1KCNH2CDK4CCND1 | |
| SCHEMBL4504747 | 0.81 | CDK2 (0.65) | CDK2CDK1KCNH2CDK4CCND1 | |
| SCHEMBL4516815 | 0.80 | CDK2 (0.65) | CDK2CDK1KCNH2CDK4CCND1 | |
| SCHEMBL4193323 | 0.79 | CDK2 (0.53) | CDK2CDK1KCNH2CDK4CCND1 | |
| SCHEMBL4196604 | 0.79 | CDK2 (0.53) | CDK2CDK1KCNH2CDK4CCND1 | |
| SCHEMBL4193135 | 0.78 | CDK2 (0.59) | CDK2CDK1KCNH2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032559-A1 | 2-HETEROCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007138268-A1 | 2-HETEROCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2007-12-06 | — | — | WO | disclosed |