Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 13/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4214047 | 0.82 | PIK3CG (0.59) | PIK3CGPIK3CAPIK3CDPIK3CBMEN1 | |
| SCHEMBL1890662 | 0.80 | PIK3CG (0.59) | PIK3CGPIK3CAPIK3CDPIK3CBMEN1 | |
| SCHEMBL4204281 | 0.80 | PIK3CG (0.53) | PIK3CGPIK3CAPIK3CDPIK3CBMEN1 | |
| SCHEMBL927884 | 0.79 | PIK3CD (0.60) | PIK3CGPIK3CAPIK3CDPIK3CBMEN1 | |
| SCHEMBL1889193 | 0.77 | PIK3CG (0.58) | PIK3CGPIK3CAPIK3CDPIK3CBMEN1 | |
| SCHEMBL1890923 | 0.76 | PIK3CG (0.60) | PIK3CGPIK3CAPIK3CDPIK3CBMEN1 | |
| SCHEMBL4200870 | 0.76 | PIK3CG (0.54) | PIK3CGPIK3CAPIK3CDPIK3CBMEN1 | |
| SCHEMBL4208518 | 0.75 | PIK3CG (0.59) | PIK3CGPIK3CAPIK3CDPIK3CB | |
| SCHEMBL4213933 | 0.75 | PIK3CG (0.70) | PIK3CGPIK3CAPIK3CDPIK3CBMEN1 | |
| SCHEMBL1887212 | 0.74 | PIK3CG (0.55) | PIK3CGPIK3CAPIK3CDPIK3CBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090029997-A1 | Thiazole Derivatives and Use Thereof | LABORATOIRES SERONO SA (CH) | 2009-01-29 | — | — | US | claimed |
| EP-1979346-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2008-10-15 | — | — | EP | claimed |
| WO-2007082956-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2007-07-26 | — | — | WO | claimed |
| US-20090029997-A1 | Thiazole Derivatives and Use Thereof | LABORATOIRES SERONO SA (CH) | 2009-01-29 | — | — | US | disclosed |
| EP-1979346-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007082956-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2007-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090029997-A1 | Thiazole Derivatives and Use Thereof | PDGFRB, PDGFRA, TEC | PIK3CG 2526/4885PIK3CA 1647/4885PIK3CD 1844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.