Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 11/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL76756 | 0.89 | F10 (0.51) | F10MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL5605979 | 0.86 | F10 (0.50) | F10MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL4203759 | 0.84 | F10 (0.53) | F10MAPT | |
| SCHEMBL3103885 | 0.84 | F10 (0.53) | F10MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL85609 | 0.83 | F10 (0.48) | F10MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL4202123 | 0.82 | F10 (0.50) | F10MAPTALDH1A1 | |
| SCHEMBL4213115 | 0.81 | F10 (0.59) | F10MAPT | |
| SCHEMBL76720 | 0.81 | F10 (0.68) | F10MAPT | |
| SCHEMBL76719 | 0.81 | F10 (0.68) | F10MAPT | |
| SCHEMBL4206705 | 0.76 | F10 (0.48) | F10MAPTNPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720844-B1 | PYRROLIDINO-1,2-DICARBOXY-1-(PHENYLAMIDE)-2-(4-(3-OXO-MORPHOLINO-4-YL)-PHENYLAMIDE) DERIVATIVES AND RELATED COMPOUNDS FOR USE AS INHIBITORS OF COAGULATION FACTOR XA IN THE TREATMENT OF THROMBO-EMBOLIC DISEASES | MERCK PATENT GMBH (DE) | 2009-04-29 | — | — | EP | disclosed |