Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenylacetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | CTSD | P07339 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylacetic Acid SCHEMBL9750914 | 0.95 | TDP1 (0.54) | TDP1L3MBTL1HDAC3HDAC4HDAC1 | |
| Diphenylacetic Acid SCHEMBL28441752 | 0.95 | TDP1 (0.54) | TDP1L3MBTL1HDAC3HDAC4HDAC1 | |
| Diphenylacetic Acid SCHEMBL4163015 | 0.95 | TDP1 (0.54) | TDP1L3MBTL1HDAC3HDAC4HDAC1 | |
| Diphenylacetic Acid SCHEMBL31376680 | 0.95 | TDP1 (0.54) | TDP1L3MBTL1HDAC3HDAC4HDAC1 | |
| Diphenylacetic Acid SCHEMBL9750920 | 0.95 | TDP1 (0.54) | TDP1L3MBTL1HDAC3HDAC4HDAC1 | |
| Diphenylacetic Acid SCHEMBL28447822 | 0.95 | TDP1 (0.54) | TDP1L3MBTL1HDAC3HDAC4HDAC1 | |
| Diphenylacetic Acid SCHEMBL31613149 | 0.95 | TDP1 (0.54) | TDP1L3MBTL1HDAC3HDAC4HDAC1 | |
| Diphenylacetic Acid SCHEMBL28446281 | 0.95 | TDP1 (0.54) | TDP1L3MBTL1HDAC3HDAC4HDAC1 | |
| Diphenylacetic Acid SCHEMBL9485692 | 0.95 | TDP1 (0.54) | TDP1L3MBTL1HDAC3HDAC4HDAC1 | |
| Diphenylacetic Acid SCHEMBL2927439 | 0.93 | TDP1 (0.52) | TDP1L3MBTL1HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189581-B1 | TOPICAL ANTI-MICROBIAL COMPOSITIONS | PROCTER & GAMBLE (US) | 2009-03-04 | — | — | EP | disclosed |