Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | PDE1A | P54750 | 2/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 4/20 | 0.35 |
| ▸ | RXRB | P28702 | 4/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474877 | 1.00 | PDE5A (0.39) | PDE5APDE1APDE1BPDE4DPDE7A | |
| SCHEMBL3946179 | 1.00 | PDE5A (0.39) | PDE5APDE1APDE1BPDE4DPDE7A | |
| SCHEMBL474994 | 0.89 | KDM4E (0.35) | AKR1C2AKR1C1 | |
| SCHEMBL209307 | 0.88 | PDE4D (0.41) | PDE5APDE1APDE1BPDE4DPDE7A | |
| SCHEMBL4067647 | 0.86 | POLB (0.37) | PDE5APDE1APDE1BPDE4DPDE7A | |
| SCHEMBL208452 | 0.83 | PDE4D (0.35) | PDE5APDE1APDE1BPDE4DPDE7A | |
| SCHEMBL4060990 | 0.81 | SRD5A2 (0.32) | PDE5APDE1APDE1BPDE4DPDE7A | |
| SCHEMBL208541 | 0.81 | SRD5A2 (0.32) | PDE5APDE1APDE1BPDE4DPDE7A | |
| SCHEMBL208778 | 0.78 | MEN1 (0.32) | PDE5APDE1APDE1BPDE4DPDE7A | |
| SCHEMBL209158 | 0.78 | MEN1 (0.32) | PDE5APDE1APDE1BPDE4DPDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029529-A1 | SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | Eli Lilly & Company (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007127693-A1 | SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-08 | — | — | WO | disclosed |