Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 18/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2639923 | 0.95 | F10 (0.52) | F10 | |
| SCHEMBL4208489 | 0.93 | F10 (0.46) | F10NPC1RAB9ATDP1MTOR | |
| SCHEMBL78034 | 0.90 | F10 (0.55) | F10NPC1RAB9ATDP1 | |
| SCHEMBL78035 | 0.90 | F10 (0.55) | F10NPC1RAB9ATDP1 | |
| SCHEMBL2639995 | 0.90 | F10 (0.58) | F10NPC1RAB9ATDP1 | |
| SCHEMBL4211411 | 0.90 | F10 (0.48) | F10 | |
| SCHEMBL4209725 | 0.89 | F10 (0.44) | F10NPC1RAB9ATDP1MTOR | |
| SCHEMBL4208665 | 0.89 | F10 (0.47) | F10MTOR | |
| SCHEMBL2640106 | 0.88 | F10 (0.43) | F10MTOR | |
| SCHEMBL2639944 | 0.87 | F10 (0.50) | F10MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720844-B1 | PYRROLIDINO-1,2-DICARBOXY-1-(PHENYLAMIDE)-2-(4-(3-OXO-MORPHOLINO-4-YL)-PHENYLAMIDE) DERIVATIVES AND RELATED COMPOUNDS FOR USE AS INHIBITORS OF COAGULATION FACTOR XA IN THE TREATMENT OF THROMBO-EMBOLIC DISEASES | MERCK PATENT GMBH (DE) | 2009-04-29 | — | — | EP | disclosed |
| EP-1791597-A2 | CARBONYL COMPOUND-CONTAINING DRUG AND THE USE THEREOF | Merck Patent GmbH (DE) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006032342-A2 | CARBONYL COMPOUND-CONTAINING DRUG AND THE USE THEREOF | MERCK PATENT GMBH (DE) | 2006-03-30 | — | — | WO | disclosed |