⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6513927 | 1.00 | — | — | |
| SCHEMBL6522689 | 1.00 | — | — | |
| SCHEMBL6513930 | 1.00 | — | — | |
| SCHEMBL6522687 | 1.00 | — | — | |
| SCHEMBL6514157 | 0.93 | DDB1 (0.38) | — | |
| SCHEMBL6514159 | 0.93 | DDB1 (0.38) | — | |
| SCHEMBL224337 | 0.93 | DDB1 (0.38) | — | |
| SCHEMBL224335 | 0.93 | DDB1 (0.38) | — | |
| SCHEMBL6278265 | 0.93 | DDB1 (0.38) | — | |
| SCHEMBL224336 | 0.93 | DDB1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513530-A4 | TETRAHYDROQUINOLINES FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX | INTREXON CORP (US) | 2009-04-01 | — | — | EP | disclosed |
| US-20050228016-A1 | TETRAHYDROQUINOLINES FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX | MICHELOTTI ENRIQUE | 2005-10-13 | — | — | US | disclosed |
| EP-1513530-A1 | TETRAHYDROQUINOLINES FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX | RheoGene, Inc. (US) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003105849-A1 | TETRAHYDROQUINOLINES FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX | RHEOGENE, INC. (US) | 2003-12-24 | — | — | WO | disclosed |