Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 17/20 | 0.73 |
| ▸ | AURKA | O14965 | 10/20 | 0.73 |
| ▸ | CCNA2 | P20248 | 13/20 | 0.69 |
| ▸ | CDK4 | P11802 | 7/20 | 0.69 |
| ▸ | CCND3 | P30281 | 7/20 | 0.69 |
| ▸ | CDK6 | Q00534 | 7/20 | 0.69 |
| ▸ | TTK | P33981 | 2/20 | 0.63 |
| ▸ | PIM1 | P11309 | 1/20 | 0.63 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.63 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.60 |
| ▸ | PLK1 | P53350 | 3/20 | 0.55 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4166117 | 0.85 | CDK2 (1.00) | CDK2AURKACCNA2CDK4CCND3 | |
| SCHEMBL4171285 | 0.84 | CDK2 (0.83) | CDK2AURKACCNA2CDK4CCND3 | |
| SCHEMBL12698391 | 0.83 | TTK (0.74) | CDK2AURKACCNA2CDK4CCND3 | |
| SCHEMBL4213229 | 0.83 | CDK2 (0.70) | CDK2AURKACCNA2CDK4CCND3 | |
| SCHEMBL15377577 | 0.81 | TTK (0.71) | CDK2AURKACCNA2CDK4CCND3 | |
| SCHEMBL4164502 | 0.81 | CDK2 (0.69) | CDK2AURKACCNA2CDK4CCND3 | |
| SCHEMBL18798565 | 0.80 | CDK2 (0.78) | CDK2AURKACCNA2CDK4CCND3 | |
| Tartaric Acid SCHEMBL31326958 | 0.80 | CDK2 (0.76) | CDK2AURKACCNA2CDK4CCND3 | |
| Trifluoroacetic Acid SCHEMBL15377699 | 0.79 | TTK (0.68) | CDK2AURKACCNA2CDK4CCND3 | |
| SCHEMBL15377682 | 0.78 | TTK (0.85) | CDK2AURKACCNA2CDK4CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482354-B2 | Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-01-27 | — | — | US | disclosed |
| US-20070185143-A1 | Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185143-A1 | Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors | MAP3K5, MAP3K9, MAP3K19 | CDK2 52/4885AURKA 159/4885CCNA2 1362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.