SCHEMBL421328

SCHEMBL421328

Cc1nc2c(c(=O)[nH]1)CSCC2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 6/20 1.00
PARP3 Q9Y6F1 2/20 1.00
PARP15 Q460N3 1/20 1.00
TNKS O95271 6/20 0.53
TNKS2 Q9H2K2 6/20 0.53
PARP2 Q9UGN5 2/20 0.50
WNT3A P56704 1/20 0.50
PARP14 Q460N5 1/20 0.50
PARP4 Q9UKK3 1/20 0.50
AXIN2 Q9Y2T1 1/20 0.50
CYP1A2 P05177 1/20 0.39
HIF1A Q16665 1/20 0.39
TYMS P04818 5/20 0.38
KDM4E B2RXH2 1/20 0.35
ALDH1A1 P00352 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
MAPK1 P28482 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28798675 0.84 PARP1 (0.72) PARP1PARP3PARP15TNKSTNKS2
SCHEMBL7782055 0.80 PARP1 (0.67) PARP1PARP3PARP15TNKSTNKS2
SCHEMBL7783296 0.79 PARP1 (0.65) PARP1PARP3PARP15TNKSTNKS2
SCHEMBL7781500 0.79 PARP1 (0.65) PARP1PARP3PARP15TNKSTNKS2
SCHEMBL7783308 0.79 PARP1 (0.65) PARP1PARP3PARP15TNKSTNKS2
SCHEMBL18711836 0.77 PARP1 (0.62) PARP1PARP3PARP15CYP1A2HIF1A
SCHEMBL7776883 0.76 PARP1 (0.60) PARP1PARP3PARP15TNKSTNKS2
SCHEMBL7781343 0.76 PARP1 (0.60) PARP1PARP3PARP15TNKSTNKS2
SCHEMBL12735626 0.74 PARP1 (0.59) PARP1PARP3PARP15TNKSTNKS2
SCHEMBL10150407 0.74 PARP1 (0.59) PARP1PARP3PARP15CYP1A2HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026106998-A1 PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA)-TARGETED POLY(ADP-RIBOSE) POLYMERASE (PARP) INHIBITOR AND RELATED COMPOSITION AND METHOD OF USE PURDUE RESEARCH FOUNDATION (US) 2026-05-21 WO claimed
WO-2025109076-A1 BIOMARKERS FOR IDENTIFYING PATIENTS HAVING TUMORS WITH HOMOLOGOUS RECOMBINATION DEFICIENCY INSTITUT CURIE (FR) 2025-05-30 WO claimed
US-20230293565-A1 USE OF WNT/BETA-CATENIN PATHWAY INHIBITORS TO BLOCK REPLICATION OF SARS-COV-2 AND OTHER PATHOGENIC VIRUSES THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2023-09-21 US claimed
CN-116249520-A Blocking replication of SARS-COV-2 and other pathogenic viruses using WNT/beta-catenin pathway inhibitors 阿尔伯塔大学理事会 2023-06-09 CN claimed
EP-4188378-A1 USE OF WNT/BETA-CATENIN PATHWAY INHIBITORS TO BLOCK REPLICATION OF SARS-COV-2 AND OTHER PATHOGENIC VIRUSES The Governors of the University of Alberta (CA) 2023-06-07 EP claimed
WO-2022020967-A1 USE OF WNT/BETA-CATENIN PATHWAY INHIBITORS TO BLOCK REPLICATION OF SARS-COV-2 AND OTHER PATHOGENIC VIRUSES THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2022-02-03 WO claimed
US-20120022026-A1 METHOD OF TREATING CANCER ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM (NL) 2012-01-26 US claimed
EP-2387403-A1 METHOD OF TREATING CANCER Academisch Medisch Centrum bij de Universiteit van Amsterdam (NL) 2011-11-23 EP claimed
US-20110253692-A1 Electrical heater for vehicle windshields and windows SCHAUBLE RICHARD EGON 2011-10-20 US claimed
WO-2010082821-A1 METHOD OF TREATING CANCER ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) 2010-07-22 WO claimed
WO-2010082813-A1 METHOD OF TREATING CANCER ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) 2010-07-22 WO claimed
WO-2026106998-A1 PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA)-TARGETED POLY(ADP-RIBOSE) POLYMERASE (PARP) INHIBITOR AND RELATED COMPOSITION AND METHOD OF USE PURDUE RESEARCH FOUNDATION (US) 2026-05-21 WO disclosed
US-20260132143-A1 HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF AMGEN INC. (US) 2026-05-14 US disclosed
EP-4705293-A1 SPIRO-HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF Amgen Inc. (US) 2026-03-11 EP disclosed
WO-2025227060-A1 HETEROCYCLIC INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 1 (USP1) IN COMBINATION WITH ADDITIONAL AGENTS FOR USE IN THE TREATMENT OF CANCER INSILICO MEDICINE IP LIMITED (CN) 2025-10-30 WO disclosed
EP-2387403-A1 METHOD OF TREATING CANCER Academisch Medisch Centrum bij de Universiteit van Amsterdam (NL) 2011-11-23 EP disclosed
US-20110253692-A1 Electrical heater for vehicle windshields and windows SCHAUBLE RICHARD EGON 2011-10-20 US disclosed
WO-2010082821-A1 METHOD OF TREATING CANCER ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) 2010-07-22 WO disclosed
WO-2010082813-A1 METHOD OF TREATING CANCER ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) 2010-07-22 WO disclosed
EP-1142881-A1 POLY(ADP-RIBOSE) POLYMERASE INHIBITORS CONSISTING OF PYRIMIDINE DERIVATIVES MEIJI SEIKA KAISHA LTD. (JP) 2001-10-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260132143-A1 HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF KRAS, NRAS, HRAS PARP1 2339/4885PARP3 1279/4885PARP15 3549/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.