Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cimetidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 known ✓ | P25021 | 3/20 | 0.66 |
| ▸ | SLC47A1 | Q96FL8 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | GLA | P06280 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | ATP4A | P20648 | 1/20 | 0.66 |
| ▸ | APEX1 | P27695 | 1/20 | 0.66 |
| ▸ | PDE4A | P27815 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.66 |
| ▸ | ATP4B | P51164 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.66 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cimetidine SCHEMBL22127096 | 0.98 | SLC47A1 (0.66) | HRH2SLC47A1MEN1SLC22A2LMNA | |
| Cimetidine SCHEMBL10859058 | 0.98 | SLC47A1 (0.69) | HRH2SLC47A1MEN1SLC22A2LMNA | |
| Cimetidine SCHEMBL2873981 | 0.98 | SLC47A1 (0.69) | HRH2SLC47A1MEN1SLC22A2LMNA | |
| Cimetidine SCHEMBL1163516 | 0.98 | SLC47A1 (0.69) | HRH2SLC47A1MEN1SLC22A2LMNA | |
| Cimetidine SCHEMBL1093 | 0.98 | SLC47A1 (0.69) | HRH2SLC47A1MEN1SLC22A2LMNA | |
| Cimetidine SCHEMBL10855575 | 0.98 | SLC47A1 (0.69) | HRH2SLC47A1MEN1SLC22A2LMNA | |
| Cimetidine SCHEMBL2873984 | 0.98 | SLC47A1 (0.69) | HRH2SLC47A1MEN1SLC22A2LMNA | |
| Cimetidine SCHEMBL10855569 | 0.98 | SLC47A1 (0.69) | HRH2SLC47A1MEN1SLC22A2LMNA | |
| Cimetidine SCHEMBL9403120 | 0.97 | SLC47A1 (0.67) | HRH2SLC47A1MEN1SLC22A2LMNA | |
| Cimetidine SCHEMBL11156753 | 0.97 | SLC47A1 (0.67) | HRH2SLC47A1MEN1SLC22A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3768 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025064646-A1 | COMPOSITIONS AND METHODS FOR WOUND HEALING AND HAIR GROWTH USING POLYELECTROLYTE COMPLEX (PEC) FILMS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2025-03-27 | — | — | WO | claimed |
| CN-118436599-A | Cimetidine hydrochloride sustained-release suspension and preparation method and application thereof | 五邑大学 | 2024-08-06 | — | — | CN | claimed |
| US-20240075049-A1 | DRUGS, THERAPEUTIC COMBINATIONS AND METHODS FOR PREVENTING VIRAL AND MICROBIAL INFECTIONS AND THEIR SEQUELAE | TOPELIA AUST LTD ACN 652 771 670 (AU) | 2024-03-07 | — | — | US | claimed |
| CN-116963744-A | Pharmaceutical, therapeutic combination and method for preventing viral and microbial infections and their sequelae | 拓比利亚欧斯特有限公司(ACN 652 771 670) | 2023-10-27 | — | — | CN | claimed |
| EP-4262813-A1 | DRUGS, THERAPEUTIC COMBINATIONS AND METHODS FOR PREVENTING VIRAL AND MICROBIAL INFECTIONS AND THEIR SEQUELAE | Topelia Aust Limited (ACN 652 771 670) (AU) | 2023-10-25 | — | — | EP | claimed |
| US-20230084144-A1 | THERAPEUTIC COMBINATIONS OF DRUGS AND METHODS OF USING THEM | CONSYNANCE THERAPEUTICS INC (US) | 2023-03-16 | — | — | US | claimed |
| EP-4076527-A1 | THERAPEUTIC COMBINATIONS OF DRUGS AND METHODS OF USING THEM | Consynance Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | claimed |
| WO-2022126207-A1 | DRUGS, THERAPEUTIC COMBINATIONS AND METHODS FOR PREVENTING VIRAL AND MICROBIAL INFECTIONS AND THEIR SEQUELAE | TOPELIA AUST LIMITED (ACN 652 771 670) (AU) | 2022-06-23 | — | — | WO | claimed |
| US-20210275531-A1 | PHOSPHODIESTERASE-5 INHIBITOR COMBINATIONS, METHODS OF MAKING, AND METHODS OF USE THEREOF | VK Research Associates Inc | 2021-09-09 | — | — | US | claimed |
| US-10874537-B2 | Intragastric volume-occupying device and method for fabricating same | OBALON THERAPEUTICS, INC. (US) | 2020-12-29 | — | — | US | claimed |
| EP-0746342-B1 | BIODEGRADABLE CONTROLLED RELEASE MELT-SPUN DELIVERY SYSTEM | BIOVAIL TECH LTD (US) | 2002-08-14 | — | — | EP | claimed |
| US-20020068718-A1 | Chondroprotective/restorative compositions and methods of use thereof | PIERCE SCOTT W (US) | 2002-06-06 | — | — | US | claimed |
| CN-1287842-A | Belt like plaster | ZHANG DELIANG (CN) | 2001-03-21 | — | — | CN | claimed |
| US-5808090-A | HEAT TREATMENT | ENDO PHARMACEUTICALS INC. (US) | 1998-09-15 | — | — | US | claimed |
| EP-0746342-A1 | BIODEGRADABLE CONTROLLED RELEASE MELT-SPUN DELIVERY SYSTEM | FUISZ TECHNOLOGIES LTD. (US) | 1996-12-11 | — | — | EP | claimed |
| US-5518730-A | Biodegradable controlled release flash flow melt-spun delivery system | FUISZ TECHNOLOGIES LTD. (US) | 1996-05-21 | — | — | US | claimed |
| EP-0746342-A4 | BIODEGRADABLE CONTROLLED RELEASE MELT-SPUN DELIVERY SYSTEM | FUISZ TECHNOLOGIES LTD (US) | 1996-01-11 | — | — | EP | claimed |
| EP-0431877-B1 | Cimetidine pharmaceutical compositions | SMITHKLINE BEECHAM LAB (FR) | 1994-10-19 | — | — | EP | claimed |
| WO-1993024154-A1 | BIODEGRADABLE CONTROLLED RELEASE MELT-SPUN DELIVERY SYSTEM | FUISZ TECHNOLOGIES, LTD. (US) | 1993-12-09 | — | — | WO | claimed |
| EP-0431877-A1 | Cimetidine pharmaceutical compositions | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1991-06-12 | — | — | EP | claimed |