Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | AR | P10275 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4218553 | 1.00 | SMN1; SMN2 (0.51) | SMN1; SMN2POLBARUSP2HTT | |
| SCHEMBL3653253 | 0.89 | SMN1; SMN2 (0.51) | SMN1; SMN2POLBARUSP2HTT | |
| SCHEMBL3653246 | 0.89 | SMN1; SMN2 (0.51) | SMN1; SMN2POLBARUSP2HTT | |
| SCHEMBL4218548 | 0.87 | SMN1; SMN2 (0.50) | SMN1; SMN2POLBARUSP2HTT | |
| SCHEMBL3691978 | 0.86 | SMN1; SMN2 (0.55) | SMN1; SMN2POLBARUSP2HTT | |
| SCHEMBL3646795 | 0.82 | SMN1; SMN2 (0.65) | SMN1; SMN2POLBARUSP2HTT | |
| SCHEMBL3645392 | 0.82 | SMN1; SMN2 (0.65) | SMN1; SMN2POLBARUSP2HTT | |
| SCHEMBL3650375 | 0.80 | USP2 (0.56) | SMN1; SMN2POLBARUSP2HTT | |
| SCHEMBL13269945 | 0.80 | USP2 (0.56) | SMN1; SMN2POLBARUSP2HTT | |
| SCHEMBL3653569 | 0.80 | USP2 (0.56) | SMN1; SMN2POLBARUSP2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288541-B2 | Piperazine amide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-10-16 | — | — | US | disclosed |
| US-20090048264-A1 | PIPERAZINE AMIDE DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048264-A1 | PIPERAZINE AMIDE DERIVATIVES | NR1H2, NR1H3, NR1I2 | SMN1; SMN2 4668/4885POLB 2115/4885AR 363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.