Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.80 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.80 |
| ▸ | BCHE | P06276 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | BACE1 | P56817 | 2/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.49 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.46 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | CCR4 | P51679 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4219788 | 1.00 | GRM2 (0.80) | GRM2GRM3BCHEACHEBACE1 | |
| SCHEMBL955657 | 0.92 | GRM2 (0.85) | GRM2GRM3BCHEACHEBACE1 | |
| SCHEMBL953673 | 0.92 | GRM2 (0.85) | GRM2GRM3BCHEACHEBACE1 | |
| SCHEMBL952352 | 0.89 | GRM2 (0.80) | GRM2GRM3BCHEACHEBACE1 | |
| SCHEMBL950584 | 0.89 | GRM2 (1.00) | GRM2GRM3BCHEACHEBACE1 | |
| SCHEMBL952354 | 0.89 | GRM2 (0.80) | GRM2GRM3BCHEACHEBACE1 | |
| SCHEMBL950586 | 0.89 | GRM2 (1.00) | GRM2GRM3BCHEACHEBACE1 | |
| Hydrochloric Acid SCHEMBL952984 | 0.88 | GRM2 (0.98) | GRM2GRM3BCHEACHEBACE1 | |
| Hydrochloric Acid SCHEMBL952981 | 0.88 | GRM2 (0.98) | GRM2GRM3BCHEACHEBACE1 | |
| SCHEMBL950893 | 0.87 | GRM2 (0.71) | GRM2GRM3BCHEACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805165-B1 | 1-(HETERO)ARYL-3-AMINO-PYRROLIDINE DERIVATIVES FOR USE AS MGLUR3 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2009-12-16 | — | — | EP | disclosed |