Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.75 |
| ▸ | AURKA | O14965 | 12/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 12/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | CIT | O14578 | 1/20 | 0.48 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | FECH | P22830 | 1/20 | 0.48 |
| ▸ | DCK | P27707 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4212767 | 0.87 | BRAF (0.71) | BRAFAURKAAURKBCYP2D6CYP2C9 | |
| SCHEMBL13969679 | 0.84 | BRAF (0.55) | BRAFAURKAAURKBCYP2D6CYP2C9 | |
| SCHEMBL4210452 | 0.82 | BRAF (0.85) | BRAFAURKAAURKBCYP2D6CYP2C9 | |
| SCHEMBL13969680 | 0.81 | BRAF (0.51) | BRAFAURKAAURKBCYP2D6CYP2C9 | |
| SCHEMBL4218373 | 0.78 | BRAF (0.68) | BRAFAURKAAURKBCYP2D6CYP2C9 | |
| SCHEMBL14160547 | 0.75 | AURKA (0.69) | AURKAAURKBCYP2D6CYP2C9PLK4 | |
| SCHEMBL4305003 | 0.75 | AURKB (0.55) | BRAFAURKAAURKBCYP2D6CYP2C9 | |
| SCHEMBL13969683 | 0.73 | BRAF (0.56) | BRAFAURKAAURKBCYP2D6CYP2C9 | |
| SCHEMBL13969814 | 0.73 | BRAF (0.57) | BRAFAURKAAURKBCYP2D6CYP2C9 | |
| SCHEMBL4322016 | 0.73 | AURKB (0.58) | BRAFAURKAAURKBCYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090018156-A1 | Pyrrolo [2,3,B] Pyridine Derivatives Useful As RAF Kinase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2009-01-15 | — | — | US | disclosed |
| US-20090018156-A1 | Pyrrolo [2,3,B] Pyridine Derivatives Useful As RAF Kinase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2009-01-15 | — | — | US | disclosed |
| WO-2007090141-A2 | PYRROLO [2, 3, B] PYRIDINE DERIVATIVES USEFUL AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018156-A1 | Pyrrolo [2,3,B] Pyridine Derivatives Useful As RAF Kinase Inhibitors | BRAF, RAF1, ARAF | BRAF 1/4885AURKA 389/4885AURKB 345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.