Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.64 |
| ▸ | KIT | P10721 | 8/20 | 0.54 |
| ▸ | FLT3 | P36888 | 7/20 | 0.54 |
| ▸ | CSF1R | P07333 | 6/20 | 0.54 |
| ▸ | LYN | P07948 | 6/20 | 0.54 |
| ▸ | FLT1 | P17948 | 6/20 | 0.54 |
| ▸ | FLT4 | P35916 | 6/20 | 0.54 |
| ▸ | BLK | P51451 | 6/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.54 |
| ▸ | RET | P07949 | 5/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.54 |
| ▸ | EPHA2 | P29317 | 5/20 | 0.54 |
| ▸ | FRK | P42685 | 5/20 | 0.54 |
| ▸ | CLK2 | P49760 | 5/20 | 0.54 |
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.54 |
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4232674 | 0.88 | KDR (0.82) | KDRKITFLT3CSF1RLYN | |
| SCHEMBL3846464 | 0.88 | KDR (0.64) | KDRKITFLT3CSF1RLYN | |
| SCHEMBL3844631 | 0.88 | KDR (0.62) | KDRKITFLT3CSF1RLYN | |
| SCHEMBL4218145 | 0.87 | KDR (0.69) | KDRKITFLT3CSF1RLYN | |
| SCHEMBL3847114 | 0.85 | KDR (0.62) | KDRKITFLT3CSF1RLYN | |
| SCHEMBL4221396 | 0.85 | KDR (0.62) | KDRKITFLT3CSF1RLYN | |
| SCHEMBL3842232 | 0.85 | KIT (0.70) | KDRKITFLT3CSF1RLYN | |
| SCHEMBL12322989 | 0.84 | KDR (0.60) | KDRKITFLT3CSF1RLYN | |
| SCHEMBL3846432 | 0.83 | KDR (0.59) | KDRKITFLT3CSF1RLYN | |
| SCHEMBL14176479 | 0.82 | KDR (0.58) | KDRKITFLT3CSF1RLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125808-A2 | 3-H-PYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-12-02 | — | — | EP | claimed |
| US-20090062273-A1 | 3-H-pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same. | BAYER SCHERING PHARMA AG (DE) | 2009-03-05 | — | — | US | claimed |
| WO-2008071456-A2 | 3-H-PYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-06-19 | — | — | WO | claimed |
| US-20090062273-A1 | 3-H-pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same. | BAYER SCHERING PHARMA AG (DE) | 2009-03-05 | — | — | US | disclosed |
| US-20090062273-A1 | 3-H-pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same. | BAYER SCHERING PHARMA AG (DE) | 2009-03-05 | — | — | US | disclosed |
| US-20090062273-A1 | 3-H-pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same. | BAYER SCHERING PHARMA AG (DE) | 2009-03-05 | — | — | US | disclosed |
| WO-2008071456-A2 | 3-H-PYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062273-A1 | 3-H-pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same. | KDR, FLT4, TIE1 | KDR 1/4885KIT 93/4885FLT3 143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.