Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 2/20 | 0.45 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 3/20 | 0.39 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4217956 | 1.00 | SCN1A (0.45) | SCN1ASCN8ADRD2HTR2AHTR2C | |
| SCHEMBL4217947 | 1.00 | SCN1A (0.45) | SCN1ASCN8ADRD2HTR2AHTR2C | |
| SCHEMBL4221277 | 1.00 | SCN1A (0.45) | SCN1ASCN8ADRD2HTR2AHTR2C | |
| SCHEMBL4231673 | 0.95 | HTR2A (0.45) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL4231670 | 0.95 | HTR2A (0.45) | DRD2HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL4221070 | 0.94 | SCN8A (0.40) | SCN1ASCN8AMAOAMAOBBCHE | |
| SCHEMBL4221078 | 0.94 | SCN8A (0.40) | SCN1ASCN8AMAOAMAOBBCHE | |
| SCHEMBL4221533 | 0.93 | CCR3 (0.42) | SCN1ASCN8ADRD2SIGMAR1MAOA | |
| SCHEMBL4221524 | 0.93 | CCR3 (0.42) | SCN1ASCN8ADRD2SIGMAR1MAOA | |
| SCHEMBL4228371 | 0.93 | CCR3 (0.42) | SCN1ASCN8ADRD2HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557127-B2 | HDAC inhibitor | ASTELLAS PHARMA INC. (JP) | 2009-07-07 | — | — | US | disclosed |
| US-20090054464-A1 | HDAC INHIBITOR | ASTELLAS PHARMA INC. (JP) | 2009-02-26 | — | — | US | disclosed |
| US-7465731-B2 | HDAC inhibitor | ASTELLAS PHARMA INC. (JP) | 2008-12-16 | — | — | US | disclosed |
| US-20060052599-A1 | HDAC inhibitor | ASTELLAS PHARMA INC. (JP) | 2006-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052599-A1 | HDAC inhibitor | HDAC1, HDAC2, HDAC11 | SCN1A 1924/4885SCN8A 2442/4885DRD2 1798/4885 |
| US-20090054464-A1 | HDAC INHIBITOR | HDAC1, HDAC2, HDAC8 | SCN1A 2419/4885SCN8A 2921/4885DRD2 1314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.