Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 17/20 | 0.76 |
| ▸ | PGR | P06401 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | FPR3 | P25089 | 1/20 | 0.56 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | GPR183 | P32249 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.56 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.56 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.56 |
| ▸ | P2RY13 | Q9BPV8 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4219168 | 1.00 | P2RY12 (0.76) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL4232361 | 1.00 | P2RY12 (0.76) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL4012773 | 1.00 | P2RY12 (0.76) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL4010214 | 1.00 | P2RY12 (0.76) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL4010212 | 1.00 | P2RY12 (0.76) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL23867216 | 0.88 | P2RY12 (0.60) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL13764358 | 0.88 | P2RY12 (0.76) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL4011841 | 0.88 | P2RY12 (0.76) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL4012276 | 0.88 | P2RY12 (0.76) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL13764359 | 0.88 | P2RY12 (0.76) | P2RY12PGRADORA3CHRM1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081433-A2 | TRIAZOLOPYRIMIDINE DERIVATIVES AS ADP P2Y12 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008054795-A2 | TRIAZOLOPYRIMIDINE DERIVATIVES AS ADP P2Y12 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-05-08 | — | — | WO | disclosed |