SCHEMBL4225928

SCHEMBL4225928

COCC(C)Oc1cc(Oc2ccc(C(=N)NO)cc2)cc(C(=O)Nc2ccn(C)n2)c1

nearest known ligand 0.73

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GCK P35557 20/20 0.73
KCNH2 Q12809 3/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1146942 1.00 GCK (0.73) GCKKCNH2
SCHEMBL4056275 0.89 GCK (0.78) GCKKCNH2
SCHEMBL2666302 0.89 GCK (0.78) GCKKCNH2
SCHEMBL2904475 0.89 GCK (0.78) GCKKCNH2
SCHEMBL1147105 0.89 GCK (0.77) GCKKCNH2
SCHEMBL13891641 0.89 GCK (0.77) GCKKCNH2
SCHEMBL1147035 0.88 GCK (0.85) GCKKCNH2
SCHEMBL14017893 0.88 GCK (0.77) GCKKCNH2
SCHEMBL2666229 0.86 GCK (0.73) GCKKCNH2
SCHEMBL4050065 0.86 GCK (0.73) GCKKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2048137-A1 Benzamide derivatives and their use as glucokinase activating agents. AstraZeneca AB (SE) 2009-04-15 EP disclosed
EP-1718624-B1 BENZAMIDE DERIVATIVES AND THEIR USE AS GLUCOKINASE ACTIVATING AGENTS ASTRAZENECA AB (SE) 2009-03-25 EP disclosed