Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 8/20 | 0.41 |
| ▸ | BACE1 | P56817 | 5/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3787453 | 0.94 | SSTR5 (0.59) | SSTR5ACHEBACE1SIGMAR1KMT2A | |
| SCHEMBL4236818 | 0.89 | SSTR5 (0.47) | SSTR5ACHEBACE1HDAC1SIGMAR1 | |
| SCHEMBL3781183 | 0.88 | SSTR5 (0.52) | SSTR5ACHEBACE1SIGMAR1 | |
| SCHEMBL4240279 | 0.87 | SSTR5 (0.50) | SSTR5ACHEBACE1MAPK8MEN1 | |
| SCHEMBL3774524 | 0.85 | SSTR5 (0.53) | SSTR5ACHEBACE1SIGMAR1ROCK2 | |
| SCHEMBL3785452 | 0.85 | SSTR5 (0.52) | SSTR5ACHEBACE1SIGMAR1MEN1 | |
| SCHEMBL4233983 | 0.85 | SSTR5 (0.47) | SSTR5ACHE | |
| SCHEMBL3774157 | 0.83 | SSTR5 (0.51) | SSTR5ACHEBACE1SIGMAR1 | |
| SCHEMBL27756066 | 0.83 | SSTR5 (0.49) | SSTR5ACHEBACE1ROCK2CCR2 | |
| SCHEMBL3782674 | 0.81 | SSTR5 (0.60) | SSTR5ACHEBACE1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001867-B1 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-07-01 | — | — | EP | disclosed |
| CN-101405284-A | Pyrimidine, quinazoline, pteridine and derivatives | HOFFMANN LA ROCHE (CH) | 2009-04-08 | — | — | CN | disclosed |