Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 14/20 | 0.74 |
| ▸ | DRD2 | P14416 | 3/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.74 |
| ▸ | HTR2A | P28223 | 2/20 | 0.74 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.74 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.74 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.74 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.74 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.74 |
| ▸ | HRH1 | P35367 | 1/20 | 0.74 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.74 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4224843 | 1.00 | CHRM1 (0.74) | CHRM1DRD2KCNH2HTR2AMCHR1 | |
| SCHEMBL1554089 | 0.85 | CHRM1 (1.00) | CHRM1DRD2KCNH2HTR2AMCHR1 | |
| SCHEMBL4237250 | 0.82 | CHRM1 (0.73) | CHRM1DRD2KCNH2HTR2AMCHR1 | |
| SCHEMBL4236803 | 0.79 | CHRM1 (0.74) | CHRM1DRD2KCNH2HTR2AMCHR1 | |
| SCHEMBL4239298 | 0.79 | CHRM1 (0.64) | CHRM1DRD2KCNH2HTR2AMCHR1 | |
| SCHEMBL4051358 | 0.78 | CHRM1 (0.83) | CHRM1DRD2KCNH2HTR2AMCHR1 | |
| SCHEMBL4049615 | 0.77 | CHRM1 (0.82) | CHRM1DRD2KCNH2HTR2AMCHR1 | |
| SCHEMBL4222231 | 0.77 | CHRM1 (1.00) | CHRM1DRD2KCNH2HTR2AMCHR1 | |
| SCHEMBL4221304 | 0.76 | CHRM1 (0.73) | CHRM1DRD2KCNH2HTR2AMCHR1 | |
| SCHEMBL4231619 | 0.76 | CHRM1 (1.00) | CHRM1DRD2KCNH2HTR2AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106534-A1 | NOVEL HETEROCYCLIC CARBOXAMIDES AS M1 AGONISTS | H. LUNDBECK A/S (DK) | 2009-09-03 | — | — | WO | claimed |
| WO-2009106534-A1 | NOVEL HETEROCYCLIC CARBOXAMIDES AS M1 AGONISTS | H. LUNDBECK A/S (DK) | 2009-09-03 | — | — | WO | disclosed |