Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 10/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 10/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4223540 | 0.94 | KDM4E (0.44) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL1749830 | 0.82 | KDM4E (0.49) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL4228313 | 0.82 | KDM4E (0.44) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL4220429 | 0.82 | KDM4E (0.44) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL4220426 | 0.82 | KDM4E (0.44) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL1749220 | 0.73 | KDM4E (0.46) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL300795 | 0.73 | KDM4E (0.59) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL301308 | 0.73 | KDM4E (0.57) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL4225570 | 0.72 | KDM4E (0.50) | KDM4EGLAALDH1A1HPGDGAA | |
| SCHEMBL300607 | 0.72 | KDM4E (0.59) | KDM4EGLAALDH1A1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078018-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | Signal Pharmaceuticals LLC (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008051494-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-05-02 | — | — | WO | disclosed |