Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4228491 | 0.92 | NPC1 (0.53) | SMN1; SMN2NPC1RAB9AYTHDC1ALDH1A1 | |
| SCHEMBL4227286 | 0.85 | NPC1 (0.46) | SMN1; SMN2NPC1RAB9AYTHDC1FLT3 | |
| SCHEMBL4227217 | 0.85 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9AYTHDC1FLT3 | |
| SCHEMBL4237005 | 0.84 | NPC1 (0.46) | SMN1; SMN2NPC1RAB9AYTHDC1FLT3 | |
| SCHEMBL4233647 | 0.83 | NPC1 (0.45) | SMN1; SMN2NPC1RAB9AYTHDC1ADORA1 | |
| SCHEMBL4237270 | 0.82 | PIK3CD (0.49) | SMN1; SMN2NPC1RAB9AYTHDC1FLT3 | |
| SCHEMBL1703502 | 0.81 | PIK3CD (0.42) | SMN1; SMN2NPC1RAB9AYTHDC1FLT3 | |
| SCHEMBL12471910 | 0.76 | NPC1 (0.55) | SMN1; SMN2NPC1RAB9AYTHDC1ALDH1A1 | |
| SCHEMBL4236551 | 0.76 | PIK3CD (0.43) | SMN1; SMN2RAB9AALDH1A1TSHRPIK3CD | |
| SCHEMBL1703383 | 0.74 | NPC1 (0.49) | SMN1; SMN2NPC1RAB9APIK3CDPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097422-A1 | THIENOPYRIMIDINONES FOR TREATMENT OF INFLAMMATORY DISORDERS AND CANCERS | Eli Lilly & Co. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008064018-A1 | THIENOPYRIMIDINONES FOR TREATMENT OF INFLAMMATORY DISORDERS AND CANCERS | ELI LILLY & CO. (US) | 2008-05-29 | — | — | WO | disclosed |