Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 16/20 | 0.56 |
| ▸ | HRH1 | P35367 | 4/20 | 0.47 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3776264 | 0.94 | SSTR5 (0.61) | SSTR5HRH1SSTR1HTR2BACHE | |
| SCHEMBL4225536 | 0.91 | SSTR5 (0.49) | SSTR5HRH1SSTR1HTR2BACHE | |
| SCHEMBL4222426 | 0.91 | SSTR5 (0.46) | SSTR5HRH1HTR2BACHEBACE1 | |
| SCHEMBL4234203 | 0.91 | SSTR5 (0.56) | SSTR5HRH1HTR2B | |
| SCHEMBL4228304 | 0.89 | SSTR5 (0.48) | SSTR5HRH1HTR2BACHEBACE1 | |
| SCHEMBL4231286 | 0.89 | SSTR5 (0.56) | SSTR5HRH1SSTR1HTR2BACHE | |
| SCHEMBL4236818 | 0.88 | SSTR5 (0.47) | SSTR5HRH1HTR2BHDAC1ACHE | |
| SCHEMBL4230567 | 0.88 | SSTR5 (0.57) | SSTR5HRH1HTR2BACHE | |
| SCHEMBL4233983 | 0.85 | SSTR5 (0.47) | SSTR5HRH1HTR2BACHE | |
| SCHEMBL3773257 | 0.85 | SSTR5 (0.55) | SSTR5HRH1SSTR1HTR2BBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001867-B1 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-07-01 | — | — | EP | disclosed |