Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 11/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4233676 | 0.92 | SSTR5 (0.41) | SSTR5DRD2DRD4DRD3SSTR1 | |
| SCHEMBL4237972 | 0.92 | SSTR5 (0.43) | SSTR5DRD2DRD4DRD3BACE1 | |
| SCHEMBL4232806 | 0.90 | SSTR5 (0.43) | SSTR5DRD2DRD4DRD3HRH1 | |
| SCHEMBL4233361 | 0.90 | SSTR5 (0.44) | SSTR5DRD2DRD4DRD3SSTR1 | |
| SCHEMBL4225160 | 0.90 | CYP11B1 (0.39) | SSTR5DRD2DRD4DRD3HRH1 | |
| SCHEMBL4231309 | 0.89 | SSTR5 (0.48) | SSTR5HRH1BACE1KCNH2 | |
| SCHEMBL4234807 | 0.89 | SSTR5 (0.45) | SSTR5DRD2DRD4DRD3SSTR1 | |
| SCHEMBL4232882 | 0.86 | SSTR5 (0.47) | SSTR5DRD2DRD4DRD3SSTR1 | |
| SCHEMBL3773257 | 0.84 | SSTR5 (0.55) | SSTR5DRD2DRD4DRD3SSTR1 | |
| SCHEMBL4235014 | 0.83 | SSTR5 (0.41) | SSTR5DRD2DRD4DRD3BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001867-B1 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-07-01 | — | — | EP | disclosed |