Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.71 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.71 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | CCR4 | P51679 | 7/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL952373 | 1.00 | GRM2 (0.71) | GRM2GRM3BCHEACHEBACE1 | |
| SCHEMBL950892 | 0.88 | GRM2 (0.71) | GRM2GRM3BCHEACHEBACE1 | |
| SCHEMBL950893 | 0.88 | GRM2 (0.71) | GRM2GRM3BCHEACHEBACE1 | |
| SCHEMBL952352 | 0.87 | GRM2 (0.80) | GRM2GRM3BCHEACHEBACE1 | |
| SCHEMBL952354 | 0.87 | GRM2 (0.80) | GRM2GRM3BCHEACHEBACE1 | |
| SCHEMBL954726 | 0.86 | GRM2 (0.68) | GRM2GRM3BCHEACHEBACE1 | |
| SCHEMBL954728 | 0.86 | GRM2 (0.68) | GRM2GRM3BCHEACHEBACE1 | |
| SCHEMBL953673 | 0.86 | GRM2 (0.85) | GRM2GRM3BCHEACHEBACE1 | |
| SCHEMBL955657 | 0.86 | GRM2 (0.85) | GRM2GRM3BCHEACHEBACE1 | |
| SCHEMBL4223928 | 0.83 | GRM2 (0.77) | GRM2GRM3BCHEACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805165-B1 | 1-(HETERO)ARYL-3-AMINO-PYRROLIDINE DERIVATIVES FOR USE AS MGLUR3 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2009-12-16 | — | — | EP | disclosed |