Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GPR3 | P46089 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4572184 | 0.83 | LRRK2 (0.54) | LRRK2RAF1MAP2K1KDM4EALDH1A1 | |
| SCHEMBL3156282 | 0.83 | LRRK2 (0.50) | LRRK2RAF1MAP2K1KDM4EALDH1A1 | |
| SCHEMBL27668262 | 0.80 | LRRK2 (0.57) | LRRK2RAF1MAP2K1KDM4EALDH1A1 | |
| SCHEMBL1346465 | 0.77 | LRRK2 (0.54) | LRRK2RAF1MAP2K1KDM4EALDH1A1 | |
| SCHEMBL4063577 | 0.77 | LRRK2 (0.48) | LRRK2RAF1MAP2K1SRCIMPDH2 | |
| SCHEMBL27668508 | 0.76 | TLR7 (0.47) | LRRK2RAF1MAP2K1KDM4EALDH1A1 | |
| SCHEMBL11940537 | 0.74 | KMT2A (0.45) | LRRK2RAF1MAP2K1KDM4EALDH1A1 | |
| SCHEMBL1164857 | 0.74 | LRRK2 (0.54) | LRRK2RAF1MAP2K1KDM4EALDH1A1 | |
| SCHEMBL1344423 | 0.74 | LRRK2 (0.54) | LRRK2RAF1MAP2K1KDM4EALDH1A1 | |
| SCHEMBL3151307 | 0.74 | LRRK2 (0.58) | LRRK2RAF1MAP2K1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090192138-A1 | COMPOUNDS | BAESCHLIN DANIEL KASPAR | 2009-07-30 | — | — | US | disclosed |
| CN-101384594-A | Condensed heterocyclic compounds useful as dpp-iv inhibitors | NOVARTIS AG (CH) | 2009-03-11 | — | — | CN | disclosed |
| EP-1966215-A1 | CONDENSED HETEROCYCLIC COMPOUNDS USEFUL AS DPP-IV INHIBITORS | Novartis AG (CH) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007071738-A1 | CONDENSED HETEROCYCLIC COMPOUNDS USEFUL AS DPP-IV INHIBITORS | NOVARTIS AG (CH) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192138-A1 | COMPOUNDS | DPP4, DPP3, DPP8 | LRRK2 3412/4885RAF1 4422/4885MAP2K1 4626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.