Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 5/20 | 0.67 |
| ▸ | AURKA | O14965 | 1/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.61 |
| ▸ | PLK1 | P53350 | 12/20 | 0.58 |
| ▸ | BRD4 | O60885 | 12/20 | 0.58 |
| ▸ | BRDT | Q58F21 | 7/20 | 0.58 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.57 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.57 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.57 |
| ▸ | EGFR | P00533 | 2/20 | 0.57 |
| ▸ | FES | P07332 | 2/20 | 0.57 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.57 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.57 |
| ▸ | CLK2 | P49760 | 2/20 | 0.57 |
| ▸ | NEK2 | P51955 | 2/20 | 0.57 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.57 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.57 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.57 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4245454 | 0.99 | PTK2 (0.68) | PTK2AURKAAURKBPLK1BRD4 | |
| SCHEMBL4239425 | 0.97 | PTK2 (0.62) | PTK2AURKAAURKBPLK1BRD4 | |
| SCHEMBL4241300 | 0.92 | AURKA (0.64) | PTK2AURKAAURKBPLK1BRD4 | |
| SCHEMBL4228054 | 0.91 | PTK2 (0.57) | PTK2AURKAAURKBPLK1BRD4 | |
| SCHEMBL4234353 | 0.89 | PTK2 (0.69) | PTK2AURKAAURKBPLK1BRD4 | |
| SCHEMBL4233250 | 0.88 | RAD52 (0.62) | PTK2AURKAAURKBPLK1BRD4 | |
| SCHEMBL4238562 | 0.84 | PTK2 (0.61) | PTK2AURKAAURKBPLK1BRD4 | |
| SCHEMBL4238559 | 0.84 | PTK2 (0.61) | PTK2AURKAAURKBPLK1BRD4 | |
| SCHEMBL4246060 | 0.82 | PTK2 (0.59) | PTK2AURKAAURKBPLK1BRD4 | |
| SCHEMBL5921305 | 0.81 | PLK1 (0.64) | PTK2AURKAAURKBPLK1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009112524-A1 | PYRIDOPYRIMIDINES AS PLK1 ( POLO-LIKE KINASE) INHIBITORS | 4SC AG (DE) | 2009-09-17 | — | — | WO | disclosed |
| EP-2100894-A1 | Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors | 4SC AG (DE) | 2009-09-16 | — | — | EP | disclosed |